Clinical features and survival of gastric cancer patients with DNA mismatch repair deficiency

Naruhiko Ikoma; Jordan Cloyd; Brian D. Badgwell; Annamaria Agnes; Miguel Rodriguez-Bigas; Jaffer A. Ajani; Y. Nancy You

doi:10.1002/jso.24926

Clinical features and survival of gastric cancer patients with DNA mismatch repair deficiency

Naruhiko Ikoma, Jordan Cloyd, Brian D. Badgwell, Annamaria Agnes, Miguel Rodriguez-Bigas, Jaffer A. Ajani, Y. Nancy You

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Patients with germline DNA mismatch repair deficiency (dMMR) have an increased risk of gastric cancer. From our institutional database, we identified 12 patients with germline dMMR gastric cancer. Ten patients (83%) underwent surgical resection, with a 5-year overall survival rate of 88%. None of the three patients who received preoperative therapy and five patients with recurrent or metastatic disease experienced a significant response to 5-fluorouracil–based chemotherapy.

Original language	English (US)
Pages (from-to)	707-709
Number of pages	3
Journal	Journal of surgical oncology
Volume	117
Issue number	4
DOIs	https://doi.org/10.1002/jso.24926
State	Published - Mar 15 2018

Keywords

DNA mismatch repair deficiency
chemotherapy
gastric cancer
surgery
survival

ASJC Scopus subject areas

Surgery
Oncology

MD Anderson CCSG core facilities

Clinical Trials Office

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10.1002/jso.24926

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title = "Clinical features and survival of gastric cancer patients with DNA mismatch repair deficiency",

abstract = "Patients with germline DNA mismatch repair deficiency (dMMR) have an increased risk of gastric cancer. From our institutional database, we identified 12 patients with germline dMMR gastric cancer. Ten patients (83%) underwent surgical resection, with a 5-year overall survival rate of 88%. None of the three patients who received preoperative therapy and five patients with recurrent or metastatic disease experienced a significant response to 5-fluorouracil–based chemotherapy.",

keywords = "DNA mismatch repair deficiency, chemotherapy, gastric cancer, surgery, survival",

author = "Naruhiko Ikoma and Jordan Cloyd and Badgwell, {Brian D.} and Annamaria Agnes and Miguel Rodriguez-Bigas and Ajani, {Jaffer A.} and You, {Y. Nancy}",

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AU - Ikoma, Naruhiko

AU - Cloyd, Jordan

AU - Badgwell, Brian D.

AU - Agnes, Annamaria

AU - Rodriguez-Bigas, Miguel

AU - Ajani, Jaffer A.

AU - You, Y. Nancy

PY - 2018/3/15

Y1 - 2018/3/15

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AB - Patients with germline DNA mismatch repair deficiency (dMMR) have an increased risk of gastric cancer. From our institutional database, we identified 12 patients with germline dMMR gastric cancer. Ten patients (83%) underwent surgical resection, with a 5-year overall survival rate of 88%. None of the three patients who received preoperative therapy and five patients with recurrent or metastatic disease experienced a significant response to 5-fluorouracil–based chemotherapy.

KW - DNA mismatch repair deficiency

KW - chemotherapy

KW - gastric cancer

KW - surgery

KW - survival

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Clinical features and survival of gastric cancer patients with DNA mismatch repair deficiency

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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