TY - JOUR
T1 - Clinical outcomes research in gynecologic oncology
AU - Melamed, Alexander
AU - Rauh-Hain, J. Alejandro
AU - Schorge, John O.
N1 - Publisher Copyright:
© 2017
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Clinical outcomes research seeks to understand the real-world manifestations of clinical care. In particular, outcomes research seeks to reveal the effects of pharmaceutical, procedural, and structural aspects of healthcare on patient outcomes, including mortality, disease control, toxicity, cost, and quality of life. Although outcomes research can utilize interventional study designs, insightful use of observational data is a defining feature of this field. Many questions in gynecologic oncology are not amenable to investigation in randomized clinical trials due to cost, feasibility, or ethical concerns. When a randomized trial is not practical or has not yet been conducted, well-designed observational studies have the potential to provide the best available evidence about the effects of clinical care. Such studies may use surveys, medical records, disease registries, and a variety of administrative data sources. Even when a randomized trial has been conducted, observational studies can be used to estimate the real-world effect of an intervention, which may differ from the results obtained in the controlled setting of a clinical trial. This article reviews the goals, methodologies, data sources, and limitations of clinical outcomes research, with a focus on gynecologic oncology.
AB - Clinical outcomes research seeks to understand the real-world manifestations of clinical care. In particular, outcomes research seeks to reveal the effects of pharmaceutical, procedural, and structural aspects of healthcare on patient outcomes, including mortality, disease control, toxicity, cost, and quality of life. Although outcomes research can utilize interventional study designs, insightful use of observational data is a defining feature of this field. Many questions in gynecologic oncology are not amenable to investigation in randomized clinical trials due to cost, feasibility, or ethical concerns. When a randomized trial is not practical or has not yet been conducted, well-designed observational studies have the potential to provide the best available evidence about the effects of clinical care. Such studies may use surveys, medical records, disease registries, and a variety of administrative data sources. Even when a randomized trial has been conducted, observational studies can be used to estimate the real-world effect of an intervention, which may differ from the results obtained in the controlled setting of a clinical trial. This article reviews the goals, methodologies, data sources, and limitations of clinical outcomes research, with a focus on gynecologic oncology.
KW - Clinical outcomes research
KW - Population-based database
UR - http://www.scopus.com/inward/record.url?scp=85021196804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021196804&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2017.06.016
DO - 10.1016/j.ygyno.2017.06.016
M3 - Review article
C2 - 28651803
AN - SCOPUS:85021196804
SN - 0090-8258
VL - 146
SP - 653
EP - 660
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -