TY - JOUR
T1 - Clinical pharmacology of timentin (ticarcillin and clavulanic acid)
AU - Bodey, Gerald P.
AU - Yeo, Edna
AU - Ho, Dah Hsi
AU - Rolston, Kenneth
AU - LeBlanc, Barbara
PY - 1985/8
Y1 - 1985/8
N2 - Ticarcillin (4 gm) and clavulanic acid (0.1 gm) were simultaneously administered as timentin to patients with cancer as therapy for infections. The pharmacokinetics of both ticarcillin and clavulanic acid were studied in 15 patients after 30-minute and 2-hour intravenous infusions. The mean (± SD) ticarcillin plasma peak concentrations after the two infusions were 341 ± 76 and 210 ± 60 μg/ml. The plasma terminal t 1 2 values of ticarcillin were 80 ± 32 and 56 ± 12 minutes. The AUCs were 631 ± 189 and 601 ± 230 mg/L · hr. The volumes of distribution of the area were 15 ± 5 and 21 ± 7 L and total clearances were 115 ± 36 and 127 ± 54 ml/min. The corresponding values for clavulanic acid after the infusions are as follows: mean peak concentrations, 5 ± 1 and 4 ± 1 μg/ml; plasma terminal t 1 2 values, 84 ± 24 and 74 ± 36 minutes; ADCs, 11 ± 3 and 11 ± 6 mg/L · hr; volumes of distribution of the area, 22 ± 3 and 32 ± 6 L; and total clearances, 170 ± 58 and 175 ± 68 ml/min.
AB - Ticarcillin (4 gm) and clavulanic acid (0.1 gm) were simultaneously administered as timentin to patients with cancer as therapy for infections. The pharmacokinetics of both ticarcillin and clavulanic acid were studied in 15 patients after 30-minute and 2-hour intravenous infusions. The mean (± SD) ticarcillin plasma peak concentrations after the two infusions were 341 ± 76 and 210 ± 60 μg/ml. The plasma terminal t 1 2 values of ticarcillin were 80 ± 32 and 56 ± 12 minutes. The AUCs were 631 ± 189 and 601 ± 230 mg/L · hr. The volumes of distribution of the area were 15 ± 5 and 21 ± 7 L and total clearances were 115 ± 36 and 127 ± 54 ml/min. The corresponding values for clavulanic acid after the infusions are as follows: mean peak concentrations, 5 ± 1 and 4 ± 1 μg/ml; plasma terminal t 1 2 values, 84 ± 24 and 74 ± 36 minutes; ADCs, 11 ± 3 and 11 ± 6 mg/L · hr; volumes of distribution of the area, 22 ± 3 and 32 ± 6 L; and total clearances, 170 ± 58 and 175 ± 68 ml/min.
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U2 - 10.1038/clpt.1985.149
DO - 10.1038/clpt.1985.149
M3 - Article
C2 - 4017415
AN - SCOPUS:0022385421
SN - 0009-9236
VL - 38
SP - 134
EP - 139
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 2
ER -