Clinical relevance of soluble HLA-I and β2-microglobulin levels in non-Hodgkin's lymphoma and Hodgkin's disease

Maher Albitar; Julie M. Vose; Marcella M. Johnson; Kim Ann Do; Amanda Day; Iman Jilani; Hagop Kantarjian; Michael Keating; Susan M. O'Brien; Srdan Verstovsek; James O. Armitage; Francis J. Giles

doi:10.1016/j.leukres.2006.02.013

Clinical relevance of soluble HLA-I and β2-microglobulin levels in non-Hodgkin's lymphoma and Hodgkin's disease

Maher Albitar, Julie M. Vose, Marcella M. Johnson, Kim Ann Do, Amanda Day, Iman Jilani, Hagop Kantarjian, Michael Keating, Susan M. O'Brien, Srdan Verstovsek, James O. Armitage, Francis J. Giles

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Plasma levels of beta-2 microglobulin (β2M), a subunit of the human leukocyte antigen-class I (HLA-I) molecule, correlate negatively with outcome in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). We examined the clinical relevance of soluble HLA-I (sHLA-I) levels in NHL and HD. Sera from consecutive NHL (n = 65) and HD (n = 37) patients were analyzed in a blinded manner. NHL and HD patients had significantly higher levels of sHLA-1 and β2M than control subjects. In NHL patients, sHLA-I levels correlated with clinical behavior in a fashion similar to that of β2M. However, multivariate analysis incorporating β2M, sHLA-I, and international prognostic index (IPI) indicated that NHL patients with elevated (>312.6 μg/100 mL) sHLA-I levels had significantly shorter survival, independent of IPI score as well as β2M. In HD patients, β2M but not sHLA-I levels were associated with clinical behavior. These findings not only establish the role of sHLA-I as an independent tumor marker in NHL that can be used to stratify patients, but also suggest that β2M and sHLA-I may reflect different biological processes in HD and NHL. Further studies are needed to assess whether the immunomodulatory properties of sHLA-I may be responsible for its divergence from β2M as an indicator of clinical behavior in HD.

Original language	English (US)
Pages (from-to)	139-145
Number of pages	7
Journal	Leukemia Research
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2006.02.013
State	Published - Feb 2007

Keywords

Beta-2 microglobulin
Hodgkin's disease
Human leukocyte antigen-class I
Immune modulation
Non-Hodgkin's lymphoma

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2006.02.013

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@article{e007f9aa50654541b675d7228c23e173,

title = "Clinical relevance of soluble HLA-I and β2-microglobulin levels in non-Hodgkin's lymphoma and Hodgkin's disease",

abstract = "Plasma levels of beta-2 microglobulin (β2M), a subunit of the human leukocyte antigen-class I (HLA-I) molecule, correlate negatively with outcome in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). We examined the clinical relevance of soluble HLA-I (sHLA-I) levels in NHL and HD. Sera from consecutive NHL (n = 65) and HD (n = 37) patients were analyzed in a blinded manner. NHL and HD patients had significantly higher levels of sHLA-1 and β2M than control subjects. In NHL patients, sHLA-I levels correlated with clinical behavior in a fashion similar to that of β2M. However, multivariate analysis incorporating β2M, sHLA-I, and international prognostic index (IPI) indicated that NHL patients with elevated (>312.6 μg/100 mL) sHLA-I levels had significantly shorter survival, independent of IPI score as well as β2M. In HD patients, β2M but not sHLA-I levels were associated with clinical behavior. These findings not only establish the role of sHLA-I as an independent tumor marker in NHL that can be used to stratify patients, but also suggest that β2M and sHLA-I may reflect different biological processes in HD and NHL. Further studies are needed to assess whether the immunomodulatory properties of sHLA-I may be responsible for its divergence from β2M as an indicator of clinical behavior in HD.",

keywords = "Beta-2 microglobulin, Hodgkin's disease, Human leukocyte antigen-class I, Immune modulation, Non-Hodgkin's lymphoma",

author = "Maher Albitar and Vose, {Julie M.} and Johnson, {Marcella M.} and Do, {Kim Ann} and Amanda Day and Iman Jilani and Hagop Kantarjian and Michael Keating and O'Brien, {Susan M.} and Srdan Verstovsek and Armitage, {James O.} and Giles, {Francis J.}",

year = "2007",

month = feb,

doi = "10.1016/j.leukres.2006.02.013",

language = "English (US)",

volume = "31",

pages = "139--145",

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T1 - Clinical relevance of soluble HLA-I and β2-microglobulin levels in non-Hodgkin's lymphoma and Hodgkin's disease

AU - Albitar, Maher

AU - Vose, Julie M.

AU - Johnson, Marcella M.

AU - Do, Kim Ann

AU - Day, Amanda

AU - Jilani, Iman

AU - Kantarjian, Hagop

AU - Keating, Michael

AU - O'Brien, Susan M.

AU - Verstovsek, Srdan

AU - Armitage, James O.

AU - Giles, Francis J.

PY - 2007/2

Y1 - 2007/2

N2 - Plasma levels of beta-2 microglobulin (β2M), a subunit of the human leukocyte antigen-class I (HLA-I) molecule, correlate negatively with outcome in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). We examined the clinical relevance of soluble HLA-I (sHLA-I) levels in NHL and HD. Sera from consecutive NHL (n = 65) and HD (n = 37) patients were analyzed in a blinded manner. NHL and HD patients had significantly higher levels of sHLA-1 and β2M than control subjects. In NHL patients, sHLA-I levels correlated with clinical behavior in a fashion similar to that of β2M. However, multivariate analysis incorporating β2M, sHLA-I, and international prognostic index (IPI) indicated that NHL patients with elevated (>312.6 μg/100 mL) sHLA-I levels had significantly shorter survival, independent of IPI score as well as β2M. In HD patients, β2M but not sHLA-I levels were associated with clinical behavior. These findings not only establish the role of sHLA-I as an independent tumor marker in NHL that can be used to stratify patients, but also suggest that β2M and sHLA-I may reflect different biological processes in HD and NHL. Further studies are needed to assess whether the immunomodulatory properties of sHLA-I may be responsible for its divergence from β2M as an indicator of clinical behavior in HD.

AB - Plasma levels of beta-2 microglobulin (β2M), a subunit of the human leukocyte antigen-class I (HLA-I) molecule, correlate negatively with outcome in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). We examined the clinical relevance of soluble HLA-I (sHLA-I) levels in NHL and HD. Sera from consecutive NHL (n = 65) and HD (n = 37) patients were analyzed in a blinded manner. NHL and HD patients had significantly higher levels of sHLA-1 and β2M than control subjects. In NHL patients, sHLA-I levels correlated with clinical behavior in a fashion similar to that of β2M. However, multivariate analysis incorporating β2M, sHLA-I, and international prognostic index (IPI) indicated that NHL patients with elevated (>312.6 μg/100 mL) sHLA-I levels had significantly shorter survival, independent of IPI score as well as β2M. In HD patients, β2M but not sHLA-I levels were associated with clinical behavior. These findings not only establish the role of sHLA-I as an independent tumor marker in NHL that can be used to stratify patients, but also suggest that β2M and sHLA-I may reflect different biological processes in HD and NHL. Further studies are needed to assess whether the immunomodulatory properties of sHLA-I may be responsible for its divergence from β2M as an indicator of clinical behavior in HD.

KW - Beta-2 microglobulin

KW - Hodgkin's disease

KW - Human leukocyte antigen-class I

KW - Immune modulation

KW - Non-Hodgkin's lymphoma

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AN - SCOPUS:33845208244

SN - 0145-2126

VL - 31

SP - 139

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JO - Leukemia Research

JF - Leukemia Research

IS - 2

ER -

Clinical relevance of soluble HLA-I and β2-microglobulin levels in non-Hodgkin's lymphoma and Hodgkin's disease

Abstract

Keywords

ASJC Scopus subject areas

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