Clinical significance of microcytosis in patients with primary myelofibrosis

Paolo Strati; Naveen Pemmaraju; Zeev Estrov; Marylou Cardenas-Turanzas; Sherry Pierce; Kate J. Newberry; Naval Daver; Jorge Cortes; Hagop Kantarjian; Srdan Verstovsek

doi:10.1016/j.leukres.2014.08.007

Clinical significance of microcytosis in patients with primary myelofibrosis

Paolo Strati, Naveen Pemmaraju, Zeev Estrov, Marylou Cardenas-Turanzas, Sherry Pierce, Kate J. Newberry, Naval Daver, Jorge Cortes, Hagop Kantarjian, Srdan Verstovsek

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Microcytosis is a relatively frequent finding in primary myelofibrosis (PMF); however its prognostic significance is unknown. We identified factors associated with microcytosis in PMF and measured its impact on outcomes. Among 725 patients with PMF, 140 (19%) showed microcytosis. In multivariate analysis, factors associated with microcytosis were absence of prior therapy, low iron, low transferrin saturation (satTF), and splenomegaly. Among 375 untreated patients, low satTF and splenomegaly were associated with microcytosis. Overall, microcytosis was associated with a higher risk of transformation to leukemia (p=0.03), but not shorter leukemia-free survival. Microcytosis in PMF may be related to dysregulation of iron homeostasis.

Original language	English (US)
Pages (from-to)	1212-1216
Number of pages	5
Journal	Leukemia Research
Volume	38
Issue number	10
DOIs	https://doi.org/10.1016/j.leukres.2014.08.007
State	Published - Oct 1 2014

Keywords

Iron homeostasis
Leukemia
Microcytosis
Primary myelofibrosis
Transferrin saturation

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

MD Anderson CCSG core facilities

Clinical Trials Office

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10.1016/j.leukres.2014.08.007

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title = "Clinical significance of microcytosis in patients with primary myelofibrosis",

abstract = "Microcytosis is a relatively frequent finding in primary myelofibrosis (PMF); however its prognostic significance is unknown. We identified factors associated with microcytosis in PMF and measured its impact on outcomes. Among 725 patients with PMF, 140 (19%) showed microcytosis. In multivariate analysis, factors associated with microcytosis were absence of prior therapy, low iron, low transferrin saturation (satTF), and splenomegaly. Among 375 untreated patients, low satTF and splenomegaly were associated with microcytosis. Overall, microcytosis was associated with a higher risk of transformation to leukemia (p=0.03), but not shorter leukemia-free survival. Microcytosis in PMF may be related to dysregulation of iron homeostasis.",

keywords = "Iron homeostasis, Leukemia, Microcytosis, Primary myelofibrosis, Transferrin saturation",

author = "Paolo Strati and Naveen Pemmaraju and Zeev Estrov and Marylou Cardenas-Turanzas and Sherry Pierce and Newberry, {Kate J.} and Naval Daver and Jorge Cortes and Hagop Kantarjian and Srdan Verstovsek",

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year = "2014",

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doi = "10.1016/j.leukres.2014.08.007",

language = "English (US)",

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T1 - Clinical significance of microcytosis in patients with primary myelofibrosis

AU - Strati, Paolo

AU - Pemmaraju, Naveen

AU - Estrov, Zeev

AU - Cardenas-Turanzas, Marylou

AU - Pierce, Sherry

AU - Newberry, Kate J.

AU - Daver, Naval

AU - Cortes, Jorge

AU - Kantarjian, Hagop

AU - Verstovsek, Srdan

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Microcytosis is a relatively frequent finding in primary myelofibrosis (PMF); however its prognostic significance is unknown. We identified factors associated with microcytosis in PMF and measured its impact on outcomes. Among 725 patients with PMF, 140 (19%) showed microcytosis. In multivariate analysis, factors associated with microcytosis were absence of prior therapy, low iron, low transferrin saturation (satTF), and splenomegaly. Among 375 untreated patients, low satTF and splenomegaly were associated with microcytosis. Overall, microcytosis was associated with a higher risk of transformation to leukemia (p=0.03), but not shorter leukemia-free survival. Microcytosis in PMF may be related to dysregulation of iron homeostasis.

AB - Microcytosis is a relatively frequent finding in primary myelofibrosis (PMF); however its prognostic significance is unknown. We identified factors associated with microcytosis in PMF and measured its impact on outcomes. Among 725 patients with PMF, 140 (19%) showed microcytosis. In multivariate analysis, factors associated with microcytosis were absence of prior therapy, low iron, low transferrin saturation (satTF), and splenomegaly. Among 375 untreated patients, low satTF and splenomegaly were associated with microcytosis. Overall, microcytosis was associated with a higher risk of transformation to leukemia (p=0.03), but not shorter leukemia-free survival. Microcytosis in PMF may be related to dysregulation of iron homeostasis.

KW - Iron homeostasis

KW - Leukemia

KW - Microcytosis

KW - Primary myelofibrosis

KW - Transferrin saturation

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DO - 10.1016/j.leukres.2014.08.007

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SN - 0145-2126

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JO - Leukemia Research

JF - Leukemia Research

IS - 10

ER -

Clinical significance of microcytosis in patients with primary myelofibrosis

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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