Clinical significance of the interaction between non-coding RNAs and the epigenetics machinery: Challenges and opportunities in oncology

Beatriz M. Maia; Rafael M. Rocha; George A. Calin

doi:10.4161/epi.26488

Clinical significance of the interaction between non-coding RNAs and the epigenetics machinery: Challenges and opportunities in oncology

Beatriz M. Maia, Rafael M. Rocha, George A. Calin

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31 Scopus citations

Abstract

Non-coding RNAs and epigenetics are remarkable mechanisms of cellular control. In this review we underline the processes by which non-coding RNAs (ncRNAs), shown to be involved in various diseases, are capable of modifying and being modified by the epigenetic machinery, emphasizing the clinical importance of this network in cancer. Many ncRNAs have been described that play important roles in the establishment and maintenance of the epigenome. However, only a few studies deeply take into account the role of ncRNAs from a clinicopathological standpoint. The wide range of interactions between the non-coding RNome and the epigenome, and the roles of these networks in the pathogenesis, prognosis and early diagnosis of many diseases, present new challenges and opportunities for future studies regarding therapeutic strategies in oncology.

Original language	English (US)
Pages (from-to)	75-80
Number of pages	6
Journal	Epigenetics
Volume	9
Issue number	1
DOIs	https://doi.org/10.4161/epi.26488
State	Published - 2014

Keywords

Cancer
Epigenetics
Prognostic
Survival
epi-miRs
lncRNAs
microRNAs (miRNAs)
ncRNAs
piRNAs

ASJC Scopus subject areas

Molecular Biology
Cancer Research

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10.4161/epi.26488

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title = "Clinical significance of the interaction between non-coding RNAs and the epigenetics machinery: Challenges and opportunities in oncology",

abstract = "Non-coding RNAs and epigenetics are remarkable mechanisms of cellular control. In this review we underline the processes by which non-coding RNAs (ncRNAs), shown to be involved in various diseases, are capable of modifying and being modified by the epigenetic machinery, emphasizing the clinical importance of this network in cancer. Many ncRNAs have been described that play important roles in the establishment and maintenance of the epigenome. However, only a few studies deeply take into account the role of ncRNAs from a clinicopathological standpoint. The wide range of interactions between the non-coding RNome and the epigenome, and the roles of these networks in the pathogenesis, prognosis and early diagnosis of many diseases, present new challenges and opportunities for future studies regarding therapeutic strategies in oncology.",

keywords = "Cancer, Epigenetics, Prognostic, Survival, epi-miRs, lncRNAs, microRNAs (miRNAs), ncRNAs, piRNAs",

author = "Maia, {Beatriz M.} and Rocha, {Rafael M.} and Calin, {George A.}",

note = "Funding Information: Calin G is The Alan M. Gewirtz Leukemia and Lymphoma Society Scholar. He is supported also as a Fellow at The University of Texas MD Anderson Research Trust, as a University of Texas System Regents Research Scholar and by the CLL Global Research Foundation. Work in Calin{\textquoteright}s laboratory is supported in part by the NIH/NCI (CA135444), a Department of Defense Breast Cancer Idea Award, Developmental Research Awards in Breast Cancer, Ovarian Cancer, Brain Cancer, Prostate Cancer, Multiple Myeloma, Leukemia (P50 CA100632), and Head and Neck (P50 CA097007) SPOREs, a SINF MDACC_DKFZ grant in CLL, a SINF grant in colon cancer, the Laura and John Arnold Foundation, the RGK Foundation, and the Estate of CG Johnson, Jr. Maia B receives scholarship from S{\~a}o Paulo Research Foundation (FAPESP), grant #2013/04075-5.",

year = "2014",

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language = "English (US)",

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journal = "Epigenetics",

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N1 - Funding Information: Calin G is The Alan M. Gewirtz Leukemia and Lymphoma Society Scholar. He is supported also as a Fellow at The University of Texas MD Anderson Research Trust, as a University of Texas System Regents Research Scholar and by the CLL Global Research Foundation. Work in Calin’s laboratory is supported in part by the NIH/NCI (CA135444), a Department of Defense Breast Cancer Idea Award, Developmental Research Awards in Breast Cancer, Ovarian Cancer, Brain Cancer, Prostate Cancer, Multiple Myeloma, Leukemia (P50 CA100632), and Head and Neck (P50 CA097007) SPOREs, a SINF MDACC_DKFZ grant in CLL, a SINF grant in colon cancer, the Laura and John Arnold Foundation, the RGK Foundation, and the Estate of CG Johnson, Jr. Maia B receives scholarship from São Paulo Research Foundation (FAPESP), grant #2013/04075-5.

PY - 2014

Y1 - 2014

N2 - Non-coding RNAs and epigenetics are remarkable mechanisms of cellular control. In this review we underline the processes by which non-coding RNAs (ncRNAs), shown to be involved in various diseases, are capable of modifying and being modified by the epigenetic machinery, emphasizing the clinical importance of this network in cancer. Many ncRNAs have been described that play important roles in the establishment and maintenance of the epigenome. However, only a few studies deeply take into account the role of ncRNAs from a clinicopathological standpoint. The wide range of interactions between the non-coding RNome and the epigenome, and the roles of these networks in the pathogenesis, prognosis and early diagnosis of many diseases, present new challenges and opportunities for future studies regarding therapeutic strategies in oncology.

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Clinical significance of the interaction between non-coding RNAs and the epigenetics machinery: Challenges and opportunities in oncology

Abstract

Keywords

ASJC Scopus subject areas

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