Abstract
Nineteen patients with metastatic breast cancer refractory to conventional therapy were treated with plasma perfusion over 200 mg of staphylococcal Protein A immobilized on a silica matrix. Fever and chills (33%), pain at the site of tumor (18%), and dyspnea (16%) were the most frequent toxic effects encountered. Four patients (21%) developed a disseminated rash which necessitated cessation of treatment. Of 16 patients evaluable for response, one achieved a minor response of chest wall disease and two had no change in hepatic metastases for 4 and 5 months' duration. Potential mechanisms of antitumor effect are discussed.
Original language | English (US) |
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Pages (from-to) | 411-413 |
Number of pages | 3 |
Journal | Cancer Treatment Reports |
Volume | 71 |
Issue number | 4 |
State | Published - 1987 |
ASJC Scopus subject areas
- Oncology
- Cancer Research