TY - JOUR
T1 - Clinicopathologic and flow cytometric DNA study of medullary thyroid carcinoma
AU - El-Naggar, A. K.
AU - Ordonez, N. G.
AU - McLemore, D.
AU - Schultz, P.
AU - Hickey, R. C.
AU - Samaan, N.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - Sixty-one patients with medullary thyroid carcinoma were investigated to establish relationships between the neoplasm's DNA content, other clinicopathologic factors, and patient survival (at least 5 years' follow-up). There were 26 (42.6%) familial and 35 (57.4%) sporadic carcinomas. Forty-two neoplasms (68.8%) were diploid and 19 (31.2%) were aneuploid by flow cytometric assessment. In univariate analysis, age, hereditary background, DNA content, calcitonin immunoreactivity, and type of surgery were strong predictors of clinical outcome. In multivariate regression analysis, none of these factors was an independent prognosticator. Patients' gender, clinical stage, histologic subtype, and amyloid content of the tumor did not influence survival.
AB - Sixty-one patients with medullary thyroid carcinoma were investigated to establish relationships between the neoplasm's DNA content, other clinicopathologic factors, and patient survival (at least 5 years' follow-up). There were 26 (42.6%) familial and 35 (57.4%) sporadic carcinomas. Forty-two neoplasms (68.8%) were diploid and 19 (31.2%) were aneuploid by flow cytometric assessment. In univariate analysis, age, hereditary background, DNA content, calcitonin immunoreactivity, and type of surgery were strong predictors of clinical outcome. In multivariate regression analysis, none of these factors was an independent prognosticator. Patients' gender, clinical stage, histologic subtype, and amyloid content of the tumor did not influence survival.
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M3 - Article
C2 - 2247844
AN - SCOPUS:0025608927
SN - 0039-6060
VL - 108
SP - 981
EP - 985
JO - Surgery
JF - Surgery
IS - 6
ER -