Clonal expansion of cells with trisomy of chromosomes 12 and X in an EBV-transformed lymphoblastoid cell line and establishment of a tumorigenic monoclonal cell line (48,XX,+X,+12)

S. Risin; T. Fujimaki; C. A. Mestriner; N. M. Brown; V. L. Hopwood; I. J. Fidler; S. Pathak

doi:10.1159/000133445

Clonal expansion of cells with trisomy of chromosomes 12 and X in an EBV-transformed lymphoblastoid cell line and establishment of a tumorigenic monoclonal cell line (48,XX,+X,+12)

S. Risin, T. Fujimaki, C. A. Mestriner, N. M. Brown, V. L. Hopwood, I. J. Fidler, S. Pathak

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Clonal expansion of cells with a certain abnormal chromosome constitution has been demonstrated in EBV-transformed lymphoblastoid cell lines, and a new monoclonal tumorigenic cell line (48,XX,+X,+12) has been established. Based on these data and our previous hypothesis that predisposition to tumor development could be associated with inherited susceptibility of certain chromosomes and chromosome regions to breakage, we emphasize that cytogenetic analysis of immortalized cell populations established from normal individuals and cancer patients might be of great importance for predicting development of different primary and secondary malignancies.

Original language	English (US)
Pages (from-to)	54-55
Number of pages	2
Journal	Cytogenetics and Cell Genetics
Volume	62
Issue number	1
DOIs	https://doi.org/10.1159/000133445
State	Published - 1993

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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Risin, S., Fujimaki, T., Mestriner, C. A., Brown, N. M., Hopwood, V. L., Fidler, I. J., & Pathak, S. (1993). Clonal expansion of cells with trisomy of chromosomes 12 and X in an EBV-transformed lymphoblastoid cell line and establishment of a tumorigenic monoclonal cell line (48,XX,+X,+12). Cytogenetics and Cell Genetics, 62(1), 54-55. https://doi.org/10.1159/000133445

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AU - Fujimaki, T.

AU - Mestriner, C. A.

AU - Brown, N. M.

AU - Hopwood, V. L.

AU - Fidler, I. J.

AU - Pathak, S.

PY - 1993

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Clonal expansion of cells with trisomy of chromosomes 12 and X in an EBV-transformed lymphoblastoid cell line and establishment of a tumorigenic monoclonal cell line (48,XX,+X,+12)

Abstract

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