@article{6057dd2fcdf04c5dbbf6b84d18399778,
title = "Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications",
abstract = "Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both cases showed near total effacement of the lymph node architecture by grade 1 FL (CD10+ and BCL2+) with accompanying in situ MCL component (CD5+ and cyclin D1+) surrounding neoplastic follicles. The diagnosis of composite FL and MCL was confirmed by detecting the t(14;18)(q32;q21) and t(11;14)(q13;q32) in the FL and MCL components, respectively. Immunoglobulin heavy chain fragment length analysis in both cases showed identical dominant monoclonal peaks in microdissected neoplastic lymphoid cells from FL and MCL components. These findings suggest a common clonal origin for the FL and MCL components in both cases.",
keywords = "Clonal relationship, Composite lymphoma, FISH, Follicular lymphoma, IgH, Mantle cell lymphoma, RLP",
author = "Shi Wang and Alexander Tzankov and Xu-Monette, {Zijun Y.} and Sylvia Hoeller and Wang, {Sa A.} and Richards, {Kristy L.} and Shanxiang Zhang and Said, {Jonathan W.} and Medeiros, {L. Jeffrey} and Young, {Ken H.}",
note = "Funding Information: Shi Wang is an honorable visiting scholar supported by the National University Hospital, Singapore. Z.Y.X.-M. is a recipient of Shannon Timmins Leukemia Endowment Fellowship and Harold C. and Mary L. Daily Endowment Fellowship Awards at The University of Texas MD Anderson Cancer Center. A.T. is a recipient of the Stiftung zur Krebsbekaempfung Zurich Grant 269 award. K.H.Y. is supported by The University of Texas MD Anderson Cancer Center Institutional R & D Fund, Institutional Research Grant Award, an MD Anderson Cancer Center SPORE Research Development Program Awards, Gundersen Lutheran Medical Foundation Award, MD Anderson Collaborative Funds with Roche Molecular System and HTG Molecular Diagnostics. This work was also partially supported by National Cancer Institute and National Institute of Health (R01CA138688, 1RC1CA146299, P50CA136411 and P50CA142509).",
year = "2013",
month = dec,
doi = "10.1016/j.humpath.2013.07.007",
language = "English (US)",
volume = "44",
pages = "2658--2667",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "12",
}