Abstract
Several cloned lines of natural suppressor (NS) cells were studied for their expression of the TCR complex. Almost all bore the CD3+CD4-CD8- surface phenotype with the α,β TCR as judged by immunofluorescent staining. Immunoprecipitation experiments showed a spot on two-dimensional gels which is characteristic of the TCR heterodimer, but neither γ- nor δ-chains could be precipitated with the appropriate antibodies. NS cells were stimulated to proliferate in vitro with anti-CD3 antibodies and PMA in the presence of irradiated spleen cells. However, anti-CD3 antibodies did not inhibit the suppressive activity of the NS cells. The role of the TCR complex in the suppressive function of these cells remains to be elucidated.
Original language | English (US) |
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Pages (from-to) | 1118-1122 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 143 |
Issue number | 4 |
State | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology