TY - JOUR
T1 - Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1
AU - Dai, Fangyan
AU - Yu, Long
AU - He, Hua
AU - Zhao, Yong
AU - Yang, Jun
AU - Zhang, Xianning
AU - Zhao, Shouyuan
N1 - Funding Information:
This work was supported by the National 973 Program and 863 High Technology Program (863-Z-02-04-01) and the National Science Foundation of China (39525015,39680019).
PY - 1999/11/15
Y1 - 1999/11/15
N2 - Serum/glucocorticoid regulated kinase (sgk) belongs to a newly emerging subfamily of the serine/threonine protein kinase family. Although human SGK shares 98% amino acid identity with rat sgk, their expression levels are regulated differently, which indicates the existence of other SGKs in humans. In this paper, we reported the cloning of human SGKL, which encodes a protein sharing 67 and 66% amino acid identity with rat sgk and human SGK, respectively. A 4.4-kb transcript of human SGKL was detected in 16 human tissues examined and was found to be most abundant in lung. By radiation hybrid mapping, the SGKL gene was located to human chromosome 8q12.1-q13.1 between markers D8S510 and D8S1797.
AB - Serum/glucocorticoid regulated kinase (sgk) belongs to a newly emerging subfamily of the serine/threonine protein kinase family. Although human SGK shares 98% amino acid identity with rat sgk, their expression levels are regulated differently, which indicates the existence of other SGKs in humans. In this paper, we reported the cloning of human SGKL, which encodes a protein sharing 67 and 66% amino acid identity with rat sgk and human SGK, respectively. A 4.4-kb transcript of human SGKL was detected in 16 human tissues examined and was found to be most abundant in lung. By radiation hybrid mapping, the SGKL gene was located to human chromosome 8q12.1-q13.1 between markers D8S510 and D8S1797.
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U2 - 10.1006/geno.1999.5969
DO - 10.1006/geno.1999.5969
M3 - Article
C2 - 10585774
AN - SCOPUS:0032756713
SN - 0888-7543
VL - 62
SP - 95
EP - 97
JO - Genomics
JF - Genomics
IS - 1
ER -