TY - JOUR
T1 - Cloning, chromosomal organization and expression analysis of Neurl, the mouse homolog of Drosophila melanogaster neutralized gene
AU - Pavlopoulos, Elias
AU - Kokkinaki, Maria
AU - Koutelou, Evangelia
AU - Mitsiadis, Thymios A.
AU - Prinos, Panagiotis
AU - Delidakis, Christos
AU - Kilpatrick, Michael W.
AU - Tsipouras, Petros
AU - Moschonas, Nicholas K.
N1 - Funding Information:
The authors wish to thank Drs. R.A. Kosher and C. Dealy for permitting the use of unpublished observations, Dr. G. Chalepakis for useful discussions and A. Pasparaki for technical assistance. This work was supported by IMBB (grant #56), University of Crete (grant #1199), and the Greek Ministry of Development (#236/234/603) (N.K.M.), HD-22610 and Coles Family Foundation (P.T.) and the Association pour la Recherche sur le Cancer (T.A.M.).
PY - 2002/4/12
Y1 - 2002/4/12
N2 - The Drosophila neuralized (neur) gene belongs to the neurogenic group of genes involved in regulating cell-cell interactions required for neural precursor development. neur mutant phenotypes include strong overcommitment to neural fates at the expense of epidermal fates. The human neuralized homolog (NEURL) has been recently determined and found to map to chromosome 10q25.1 within the region frequently deleted in malignant astrocytomas. Because of its potential importance in developmental processes, we analyzed the structure of the mouse homolog, Neurl, and its expression pattern in embryonic tissues. Neurl activity is detected from early developmental stages in several tissues and organs including neural tissues, limbs, the skeletal system, sense organs and internal organs undergoing epithelial-mesenchymal interactions. Neurl encodes a polypeptide associated with the plasma membrane but also detected in the cytoplasm. Similarly to the Drosophila gene, mammalian neuralized may code for an important regulatory factor.
AB - The Drosophila neuralized (neur) gene belongs to the neurogenic group of genes involved in regulating cell-cell interactions required for neural precursor development. neur mutant phenotypes include strong overcommitment to neural fates at the expense of epidermal fates. The human neuralized homolog (NEURL) has been recently determined and found to map to chromosome 10q25.1 within the region frequently deleted in malignant astrocytomas. Because of its potential importance in developmental processes, we analyzed the structure of the mouse homolog, Neurl, and its expression pattern in embryonic tissues. Neurl activity is detected from early developmental stages in several tissues and organs including neural tissues, limbs, the skeletal system, sense organs and internal organs undergoing epithelial-mesenchymal interactions. Neurl encodes a polypeptide associated with the plasma membrane but also detected in the cytoplasm. Similarly to the Drosophila gene, mammalian neuralized may code for an important regulatory factor.
KW - Malignant astrocytoma
KW - Mouse embryo development
KW - NEUZ domain
KW - Neurogenic gene
KW - RING finger domain
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U2 - 10.1016/S0167-4781(01)00330-X
DO - 10.1016/S0167-4781(01)00330-X
M3 - Article
C2 - 11997106
AN - SCOPUS:0037066617
SN - 0167-4781
VL - 1574
SP - 375
EP - 382
JO - Biochimica et Biophysica Acta - Gene Structure and Expression
JF - Biochimica et Biophysica Acta - Gene Structure and Expression
IS - 3
ER -