Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata

Chenlin Hu; Gary Fong; Sebastian Wurster; Dimitrios P. Kontoyiannis; Nicholas D. Beyda

doi:10.1128/spectrum.01837-21

Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata

Chenlin Hu, Gary Fong, Sebastian Wurster, Dimitrios P. Kontoyiannis, Nicholas D. Beyda

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Article › peer-review

Abstract

Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host Galleria mellonella than the other paired set. No virulence difference between the paired index and FKS strains was observed. These findings imply a potential link of clumping morphology with virulence in C. glabrata that is uncoupled from FKS-mediated echinocandin resistance.

Original language	English (US)
Article number	e01837-21
Journal	Microbiology spectrum
Volume	10
Issue number	1
DOIs	https://doi.org/10.1128/spectrum.01837-21
State	Published - Feb 2022

Keywords

Candida glabrata
Chitin
Echinocandin resistance
Morphology
Virulence
Yeast

ASJC Scopus subject areas

Physiology
Ecology
General Immunology and Microbiology
Genetics
Microbiology (medical)
Cell Biology
Infectious Diseases

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10.1128/spectrum.01837-21

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title = "Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata",

abstract = "Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host Galleria mellonella than the other paired set. No virulence difference between the paired index and FKS strains was observed. These findings imply a potential link of clumping morphology with virulence in C. glabrata that is uncoupled from FKS-mediated echinocandin resistance.",

keywords = "Candida glabrata, Chitin, Echinocandin resistance, Morphology, Virulence, Yeast",

author = "Chenlin Hu and Gary Fong and Sebastian Wurster and Kontoyiannis, {Dimitrios P.} and Beyda, {Nicholas D.}",

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language = "English (US)",

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T1 - Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata

AU - Hu, Chenlin

AU - Fong, Gary

AU - Wurster, Sebastian

AU - Kontoyiannis, Dimitrios P.

AU - Beyda, Nicholas D.

PY - 2022/2

Y1 - 2022/2

N2 - Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host Galleria mellonella than the other paired set. No virulence difference between the paired index and FKS strains was observed. These findings imply a potential link of clumping morphology with virulence in C. glabrata that is uncoupled from FKS-mediated echinocandin resistance.

AB - Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host Galleria mellonella than the other paired set. No virulence difference between the paired index and FKS strains was observed. These findings imply a potential link of clumping morphology with virulence in C. glabrata that is uncoupled from FKS-mediated echinocandin resistance.

KW - Candida glabrata

KW - Chitin

KW - Echinocandin resistance

KW - Morphology

KW - Virulence

KW - Yeast

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AN - SCOPUS:85124299642

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JO - Microbiology spectrum

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ER -

Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata

Abstract

Keywords

ASJC Scopus subject areas

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