TY - JOUR
T1 - Clusterin expression correlates with stage and presence of large cells in mycosis fungoides
AU - Chandra, Pranil
AU - Plaza, Jose A.
AU - Zuo, Zhuang
AU - Diwan, A. Hafeez
AU - Koeppen, Hartmut
AU - Duvic, Madeleine
AU - Medeiros, L Jeffrey
AU - Prieto, Victor
PY - 2009/4
Y1 - 2009/4
N2 - Clusterin expression is common in systemic and cutaneous anaplastic large cell lymphoma (ALCL). Mycosis fungoides (MF) in large cell transformation can resemble ALCL. In this study, we immunohistochemically assessed for clusterin in 97 skin biopsy specimens, including 70 MF cases and 27 other cutaneous neoplasms including ALCL, peripheral T-cell lymphoma unspecified (PTCL), and lymphomatoid papulosis (LyP). Clusterin was positive in 36 (51%) of 70 cases of MF and correlated with clinical stage in 68 cases: 3 of 21 stage I, 11 of 20 stage II, and 23 of 27 stage III/IV. Clusterin expression also correlated with type of skin lesion (3/19 patch, 13/28 plaque, and 20/23 tumor/erythroderma) and number of large cells (6/30 small cell, 12/18 with increased large cells, and 18/22 with large cell transformation). Clusterin expression was not specific for MF as it also was positive in 3 of 3 cases of LyP, 2 of 2 systemic ALCL cases involving skin, 7 of 16 cutaneous ALCLs, and 1 of 6 PTCLs.
AB - Clusterin expression is common in systemic and cutaneous anaplastic large cell lymphoma (ALCL). Mycosis fungoides (MF) in large cell transformation can resemble ALCL. In this study, we immunohistochemically assessed for clusterin in 97 skin biopsy specimens, including 70 MF cases and 27 other cutaneous neoplasms including ALCL, peripheral T-cell lymphoma unspecified (PTCL), and lymphomatoid papulosis (LyP). Clusterin was positive in 36 (51%) of 70 cases of MF and correlated with clinical stage in 68 cases: 3 of 21 stage I, 11 of 20 stage II, and 23 of 27 stage III/IV. Clusterin expression also correlated with type of skin lesion (3/19 patch, 13/28 plaque, and 20/23 tumor/erythroderma) and number of large cells (6/30 small cell, 12/18 with increased large cells, and 18/22 with large cell transformation). Clusterin expression was not specific for MF as it also was positive in 3 of 3 cases of LyP, 2 of 2 systemic ALCL cases involving skin, 7 of 16 cutaneous ALCLs, and 1 of 6 PTCLs.
KW - Anaplastic large cell lymphoma
KW - Clusterin
KW - Mycosis fungoides
KW - T-cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=65349158239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65349158239&partnerID=8YFLogxK
U2 - 10.1309/AJCPH43ZDVLSOSNB
DO - 10.1309/AJCPH43ZDVLSOSNB
M3 - Article
C2 - 19289586
AN - SCOPUS:65349158239
SN - 0002-9173
VL - 131
SP - 511
EP - 515
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 4
ER -