Abstract
Antigen-specific T cell responses have primarily been considered in terms of activation signals delivered through the TCR and the co-stimulatory molecule CD28. In the past few years, studies have demonstrated the critical importance of inhibitory signals for regulating lymphocyte activation. CD28 and its homologue cytotoxic T lymphocyte antigen-4 (CTLA-4) share the same counter-receptors on antigen-presenting cells, but recent experiments have shown that CD28 and CTLA-4 have opposite effects on T cell activation. The mechanisms responsible for integrating these activation and inhibitory signals at the cellular and molecular levels are just beginning to be elucidated.
Original language | English (US) |
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Pages (from-to) | 396-404 |
Number of pages | 9 |
Journal | Current Opinion in Immunology |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology