Cohort study among workers exposed to benzene in China: I. General methods and resources

S. ‐N Yin; M. S. Linet; R. B. Hayes; G. ‐L Li; M. Dosemeci; Y. ‐Z Wang; W. ‐H Chow; Z. ‐L Jiang; S. Wacholder; W. ‐U Zhang; T. ‐R Dai; X. ‐J Chao; X. ‐C Zhang; P. ‐Z Ye; Q. ‐R Kou; J. ‐F Meng; J. ‐S Zho; X. ‐F Lin; C. ‐Y Ding; R. Kneller; W. J. Blot

doi:10.1002/ajim.4700260312

Cohort study among workers exposed to benzene in China: I. General methods and resources

S. ‐N Yin, M. S. Linet, R. B. Hayes, G. ‐L Li, M. Dosemeci, Y. ‐Z Wang, W. ‐H Chow, Z. ‐L Jiang, S. Wacholder, W. ‐U Zhang, T. ‐R Dai, X. ‐J Chao, X. ‐C Zhang, P. ‐Z Ye, Q. ‐R Kou, J. ‐F Meng, J. ‐S Zho, X. ‐F Lin, C. ‐Y Ding, R. KnellerW. J. Blot

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Abstract

Benzene is recognized internationally as a leukemogen, but the available data to clarify dose‐response relationships and examine risks of malignancies other than leukemia are sparse. A collaborative study was therefore carried out to expand on a previous retrospective cohort mortality study of Chinese benzene‐exposed workers. Methods and resources used in the 16‐year follow‐up of 74,828 benzene‐exposed and 35,805 unex‐posed workers employed for any length of time during 1972–1987 in 712 factories in 12 cities in China are described. Details are provided of the study organization, assessment of benzene exposures since 1949, characterization of factories and workers by exposure status, city, and sex, identification and confirmation of cancers and other deaths, and quality control procedures. The distinguishing features of the study are discussed in relation to earlier cohort studies, and study limitations as well as strengths are presented.

Original language	English (US)
Pages (from-to)	383-400
Number of pages	18
Journal	American Journal of Industrial Medicine
Volume	26
Issue number	3
DOIs	https://doi.org/10.1002/ajim.4700260312
State	Published - Sep 1994
Externally published	Yes

Keywords

benzene
cancer
hematopoietic neoplasms
leukemia
occupational exposure

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1002/ajim.4700260312

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Yin, S. N., Linet, M. S., Hayes, R. B., Li, G. L., Dosemeci, M., Wang, Y. Z., Chow, W. H., Jiang, Z. L., Wacholder, S., Zhang, W. U., Dai, T. R., Chao, X. J., Zhang, X. C., Ye, P. Z., Kou, Q. R., Meng, J. F., Zho, J. S., Lin, X. F., Ding, C. Y., ... Blot, W. J. (1994). Cohort study among workers exposed to benzene in China: I. General methods and resources. American Journal of Industrial Medicine, 26(3), 383-400. https://doi.org/10.1002/ajim.4700260312

Yin, SN, Linet, MS, Hayes, RB, Li, GL, Dosemeci, M, Wang, YZ, Chow, WH, Jiang, ZL, Wacholder, S, Zhang, WU, Dai, TR, Chao, XJ, Zhang, XC, Ye, PZ, Kou, QR, Meng, JF, Zho, JS, Lin, XF, Ding, CY, Kneller, R & Blot, WJ 1994, 'Cohort study among workers exposed to benzene in China: I. General methods and resources', American Journal of Industrial Medicine, vol. 26, no. 3, pp. 383-400. https://doi.org/10.1002/ajim.4700260312

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abstract = "Benzene is recognized internationally as a leukemogen, but the available data to clarify dose‐response relationships and examine risks of malignancies other than leukemia are sparse. A collaborative study was therefore carried out to expand on a previous retrospective cohort mortality study of Chinese benzene‐exposed workers. Methods and resources used in the 16‐year follow‐up of 74,828 benzene‐exposed and 35,805 unex‐posed workers employed for any length of time during 1972–1987 in 712 factories in 12 cities in China are described. Details are provided of the study organization, assessment of benzene exposures since 1949, characterization of factories and workers by exposure status, city, and sex, identification and confirmation of cancers and other deaths, and quality control procedures. The distinguishing features of the study are discussed in relation to earlier cohort studies, and study limitations as well as strengths are presented.",

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AU - Dosemeci, M.

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AU - Chao, X. ‐J

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AU - Ye, P. ‐Z

AU - Kou, Q. ‐R

AU - Meng, J. ‐F

AU - Zho, J. ‐S

AU - Lin, X. ‐F

AU - Ding, C. ‐Y

AU - Kneller, R.

AU - Blot, W. J.

PY - 1994/9

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AB - Benzene is recognized internationally as a leukemogen, but the available data to clarify dose‐response relationships and examine risks of malignancies other than leukemia are sparse. A collaborative study was therefore carried out to expand on a previous retrospective cohort mortality study of Chinese benzene‐exposed workers. Methods and resources used in the 16‐year follow‐up of 74,828 benzene‐exposed and 35,805 unex‐posed workers employed for any length of time during 1972–1987 in 712 factories in 12 cities in China are described. Details are provided of the study organization, assessment of benzene exposures since 1949, characterization of factories and workers by exposure status, city, and sex, identification and confirmation of cancers and other deaths, and quality control procedures. The distinguishing features of the study are discussed in relation to earlier cohort studies, and study limitations as well as strengths are presented.

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Cohort study among workers exposed to benzene in China: I. General methods and resources

Abstract

Keywords

ASJC Scopus subject areas

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