Coincident primary breast lymphoma and gastrointestinal stromal tumor: Case series and molecular mechanisms

Ethan B. Ludmir; Tyler Gutschenritter; Chelsea C. Pinnix; Jillian R. Gunther; Loretta J. Nastoupil; Joseph D. Khoury; L. Jeffrey Medeiros; Bouthaina S. Dabaja; Sarah A. Milgrom

doi:10.2147/OTT.S159843

Coincident primary breast lymphoma and gastrointestinal stromal tumor: Case series and molecular mechanisms

Ethan B. Ludmir, Tyler Gutschenritter, Chelsea C. Pinnix, Jillian R. Gunther, Loretta J. Nastoupil, Joseph D. Khoury, L. Jeffrey Medeiros, Bouthaina S. Dabaja, Sarah A. Milgrom

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3 Scopus citations

Abstract

Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast lymphoma, an uncommon subtype of extranodal NHL. We propose that the exceedingly low likelihood of both these cancers occurring in these two patients by chance warrants examination for possible common oncogenic pathways in these lesions, possibly involving shared anti-apoptotic mechanisms. Further research is vital to elucidate common oncogenic pathways between such rare lesions.

Original language	English (US)
Pages (from-to)	8937-8942
Number of pages	6
Journal	OncoTargets and Therapy
Volume	11
DOIs	https://doi.org/10.2147/OTT.S159843
State	Published - 2018

Keywords

Anti-apoptosis
Diffuse large B-cell lymphoma
Gastrointestinal stromal tumor
Mucosa-associated lymphoid tissue lymphoma
Primary breast lymphoma

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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10.2147/OTT.S159843

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title = "Coincident primary breast lymphoma and gastrointestinal stromal tumor: Case series and molecular mechanisms",

abstract = "Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast lymphoma, an uncommon subtype of extranodal NHL. We propose that the exceedingly low likelihood of both these cancers occurring in these two patients by chance warrants examination for possible common oncogenic pathways in these lesions, possibly involving shared anti-apoptotic mechanisms. Further research is vital to elucidate common oncogenic pathways between such rare lesions.",

keywords = "Anti-apoptosis, Diffuse large B-cell lymphoma, Gastrointestinal stromal tumor, Mucosa-associated lymphoid tissue lymphoma, Primary breast lymphoma",

author = "Ludmir, {Ethan B.} and Tyler Gutschenritter and Pinnix, {Chelsea C.} and Gunther, {Jillian R.} and Nastoupil, {Loretta J.} and Khoury, {Joseph D.} and {Jeffrey Medeiros}, L. and Dabaja, {Bouthaina S.} and Milgrom, {Sarah A.}",

note = "Publisher Copyright: {\textcopyright} 2018 Ludmir et al.",

year = "2018",

doi = "10.2147/OTT.S159843",

language = "English (US)",

volume = "11",

pages = "8937--8942",

journal = "OncoTargets and Therapy",

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T1 - Coincident primary breast lymphoma and gastrointestinal stromal tumor

T2 - Case series and molecular mechanisms

AU - Ludmir, Ethan B.

AU - Gutschenritter, Tyler

AU - Pinnix, Chelsea C.

AU - Gunther, Jillian R.

AU - Nastoupil, Loretta J.

AU - Khoury, Joseph D.

AU - Jeffrey Medeiros, L.

AU - Dabaja, Bouthaina S.

AU - Milgrom, Sarah A.

PY - 2018

Y1 - 2018

N2 - Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast lymphoma, an uncommon subtype of extranodal NHL. We propose that the exceedingly low likelihood of both these cancers occurring in these two patients by chance warrants examination for possible common oncogenic pathways in these lesions, possibly involving shared anti-apoptotic mechanisms. Further research is vital to elucidate common oncogenic pathways between such rare lesions.

AB - Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast lymphoma, an uncommon subtype of extranodal NHL. We propose that the exceedingly low likelihood of both these cancers occurring in these two patients by chance warrants examination for possible common oncogenic pathways in these lesions, possibly involving shared anti-apoptotic mechanisms. Further research is vital to elucidate common oncogenic pathways between such rare lesions.

KW - Anti-apoptosis

KW - Diffuse large B-cell lymphoma

KW - Gastrointestinal stromal tumor

KW - Mucosa-associated lymphoid tissue lymphoma

KW - Primary breast lymphoma

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JO - OncoTargets and Therapy

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ER -

Coincident primary breast lymphoma and gastrointestinal stromal tumor: Case series and molecular mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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