TY - JOUR
T1 - Collagenous myofibroblastic tumor of the mandible
T2 - Case report of a unique locally aggressive neoplasm
AU - Nash, Jason W.
AU - Hessel, Amy C.
AU - Vigneswaran, Nadarajah
AU - El-Naggar, Adel K.
PY - 2010/3
Y1 - 2010/3
N2 - We report a locally aggressive collagenous myofibroblastic neoplasm of the mandible in an 18-year-old male. Clinically, the lesion presented with rapid growth and irregular mandibular bone destruction. Grossly, the tumor was 10 cm in greatest dimension, light-tan, firm, and involving the posterior one-thirds of the body and inferior half of the left mandibular ramus. Histologically, the lesion was composed of a loose spindle cell proliferation interspersed with periodic dense bands of collagen. The spindle cells reacted positively to smooth muscle actin, calponin, and focally to desmin and were negative for S-100, pan-cytokeratin, CD99, CD34 and caldesmon, supporting myofibroblastic derivation. At our 4 year follow-up, the patient remained free of local recurrence and surgery related complications. The clinicopathologic findings and the differential diagnosis of this lesion is presented and discussed.
AB - We report a locally aggressive collagenous myofibroblastic neoplasm of the mandible in an 18-year-old male. Clinically, the lesion presented with rapid growth and irregular mandibular bone destruction. Grossly, the tumor was 10 cm in greatest dimension, light-tan, firm, and involving the posterior one-thirds of the body and inferior half of the left mandibular ramus. Histologically, the lesion was composed of a loose spindle cell proliferation interspersed with periodic dense bands of collagen. The spindle cells reacted positively to smooth muscle actin, calponin, and focally to desmin and were negative for S-100, pan-cytokeratin, CD99, CD34 and caldesmon, supporting myofibroblastic derivation. At our 4 year follow-up, the patient remained free of local recurrence and surgery related complications. The clinicopathologic findings and the differential diagnosis of this lesion is presented and discussed.
KW - Mandible
KW - Mesenchymal tumors
KW - Myofibroblastic neoplasm
KW - Odontogenic tumors
UR - http://www.scopus.com/inward/record.url?scp=77952885729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952885729&partnerID=8YFLogxK
U2 - 10.1007/s12105-009-0154-x
DO - 10.1007/s12105-009-0154-x
M3 - Article
C2 - 20237988
AN - SCOPUS:77952885729
SN - 1936-055X
VL - 4
SP - 44
EP - 48
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 1
ER -