Colocalization of the rat homolog of the von Hippel Lindau (Vhl)gene and the plasma membrane Ca⁺⁺ transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3 → 42.1

Using fluorescence in situ hybridization, we localized the rat homolog of the von Hippel-Lindau gene (Vhl) to rat chromosome band 4q41.3 → q42.1. We also mapped the gene encoding the plasma membrane Ca⁺⁺-transporting ATPase isoform 2 (Atp2b2) to the same chromosome subregion. These two genes together with Rafl appear to be members of a large syntenic gene cluster that maps to human chromosome bands 3p25 → p26, mouse chromosome bands 6 C3 → E, and rat chromosome bands 4q41 → q42. Cytogenetic analysis of NRK 52E cells derived from immortalized normal rat kidney epithelial cells revealed an inverted duplication of the region containing this gene cluster.