TY - JOUR
T1 - Colonoscopic full-thickness resection of the colon in a porcine model as a prelude to endoscopic surgery of difficult colon polyps
T2 - a novel technique (with videos)
AU - Raju, Gottumukkala S.
AU - Malhotra, Advitya
AU - Ahmed, Ijaz
N1 - Funding Information:
DISCLOSURE: The following author disclosed financial relationships relevant to this publication: G. S. Raju has received research support from Pentax Medical, Olympus, Ethicon Endo-Surgery Inc, Boston Scientific. All other authors disclosed no financial relationship relevant to this publication.
PY - 2009/7
Y1 - 2009/7
N2 - Background: Colonoscopic full-thickness resection (CFTR) of the colon may obviate the need for surgical resection of benign lesions. Objective: To develop an animal model for CFTR of the colon followed by endoscopic suture closure with through-the-endoscope devices. Design: Pilot study. Setting: University medical center. Animals: Twenty pigs. Interventions: A 2-cm circular area was resected on the antimesenteric side of the colon (phase 1, n = 10) and on the mesenteric side (phase 2, n = 10) by using an insulated tip knife cut followed by the use of a grasping forceps and a snare to resect and retrieve the specimen. The tissue apposition system was used to close the defect. Main Outcome Measurements: Resection and closure times were recorded. The animals were euthanized at 2 weeks and examined for peritonitis, adhesions, wound healing, and T-tag injury to adjacent viscera. Results: The CFTR was successful in all 20 attempts. The median resection time was 6 minutes (range 2.5-35 minutes). Suture closure was successful in 19 animals. It took a median time of 41 minutes (range 21-125 minutes) and 4 sutures to close the defect. Eighteen animals survived without clinical signs of distress; there was a well-healed scar without peritonitis or distant adhesions on necropsy at 2 weeks. One animal failed to thrive, and necropsy revealed mild peritonitis, small abscesses, distant adhesions, and a 2-mm hole at the suture site. Two of the 132 T-tags were inserted in the adjacent viscera. Limitations: Colon resection in the proximal colon was not studied. Conclusions: In this animal model, CFTR of the colon followed by suture closure can be accomplished successfully by using through-the-endoscope devices.
AB - Background: Colonoscopic full-thickness resection (CFTR) of the colon may obviate the need for surgical resection of benign lesions. Objective: To develop an animal model for CFTR of the colon followed by endoscopic suture closure with through-the-endoscope devices. Design: Pilot study. Setting: University medical center. Animals: Twenty pigs. Interventions: A 2-cm circular area was resected on the antimesenteric side of the colon (phase 1, n = 10) and on the mesenteric side (phase 2, n = 10) by using an insulated tip knife cut followed by the use of a grasping forceps and a snare to resect and retrieve the specimen. The tissue apposition system was used to close the defect. Main Outcome Measurements: Resection and closure times were recorded. The animals were euthanized at 2 weeks and examined for peritonitis, adhesions, wound healing, and T-tag injury to adjacent viscera. Results: The CFTR was successful in all 20 attempts. The median resection time was 6 minutes (range 2.5-35 minutes). Suture closure was successful in 19 animals. It took a median time of 41 minutes (range 21-125 minutes) and 4 sutures to close the defect. Eighteen animals survived without clinical signs of distress; there was a well-healed scar without peritonitis or distant adhesions on necropsy at 2 weeks. One animal failed to thrive, and necropsy revealed mild peritonitis, small abscesses, distant adhesions, and a 2-mm hole at the suture site. Two of the 132 T-tags were inserted in the adjacent viscera. Limitations: Colon resection in the proximal colon was not studied. Conclusions: In this animal model, CFTR of the colon followed by suture closure can be accomplished successfully by using through-the-endoscope devices.
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U2 - 10.1016/j.gie.2009.02.022
DO - 10.1016/j.gie.2009.02.022
M3 - Article
C2 - 19559838
AN - SCOPUS:67549135626
SN - 0016-5107
VL - 70
SP - 159
EP - 165
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 1
ER -