Combination chemotherapy in vitro with adriamycin. Observations of additive, antagonistic, and synergistic effects when used in two drug combinations on cultured human lymphoma cells

B. Drewinko; T. L. Loo; B. Brown; J. A. Gottlieb; E. J. Freireich

Combination chemotherapy in vitro with adriamycin. Observations of additive, antagonistic, and synergistic effects when used in two drug combinations on cultured human lymphoma cells

B. Drewinko, T. L. Loo, B. Brown, J. A. Gottlieb, E. J. Freireich

Leukemia

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117 Scopus citations

Abstract

Adriamycin was paired with 12 other chemotherapeutic drugs in a search for possible synergistic pairs. Cell lethality was investigated by the colony formation method utilizing a long term human lymphoma cell line. Additive effects were noted with CCNU, ara C, prednisolone, DDP, VP 16 and Yoshi, and mild synergistic effects with BLEO and CS. Adriamycin reduced the killing ability of BCNU and MeCCNU when applied simultaneously. This antagonistic effect was canceled by sequential incubation with each drug. It appears that no significant synergism can be expected by simultaneous pairing of adriamycin with some currently available chemotherapeutic agents.

Original language	English (US)
Pages (from-to)	187-195
Number of pages	9
Journal	Cancer biochemistry biophysics
Volume	1
Issue number	4
State	Published - 1976

ASJC Scopus subject areas

Biophysics
Cancer Research

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title = "Combination chemotherapy in vitro with adriamycin. Observations of additive, antagonistic, and synergistic effects when used in two drug combinations on cultured human lymphoma cells",

abstract = "Adriamycin was paired with 12 other chemotherapeutic drugs in a search for possible synergistic pairs. Cell lethality was investigated by the colony formation method utilizing a long term human lymphoma cell line. Additive effects were noted with CCNU, ara C, prednisolone, DDP, VP 16 and Yoshi, and mild synergistic effects with BLEO and CS. Adriamycin reduced the killing ability of BCNU and MeCCNU when applied simultaneously. This antagonistic effect was canceled by sequential incubation with each drug. It appears that no significant synergism can be expected by simultaneous pairing of adriamycin with some currently available chemotherapeutic agents.",

author = "B. Drewinko and Loo, {T. L.} and B. Brown and Gottlieb, {J. A.} and Freireich, {E. J.}",

year = "1976",

language = "English (US)",

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pages = "187--195",

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T1 - Combination chemotherapy in vitro with adriamycin. Observations of additive, antagonistic, and synergistic effects when used in two drug combinations on cultured human lymphoma cells

AU - Drewinko, B.

AU - Loo, T. L.

AU - Brown, B.

AU - Gottlieb, J. A.

AU - Freireich, E. J.

PY - 1976

Y1 - 1976

N2 - Adriamycin was paired with 12 other chemotherapeutic drugs in a search for possible synergistic pairs. Cell lethality was investigated by the colony formation method utilizing a long term human lymphoma cell line. Additive effects were noted with CCNU, ara C, prednisolone, DDP, VP 16 and Yoshi, and mild synergistic effects with BLEO and CS. Adriamycin reduced the killing ability of BCNU and MeCCNU when applied simultaneously. This antagonistic effect was canceled by sequential incubation with each drug. It appears that no significant synergism can be expected by simultaneous pairing of adriamycin with some currently available chemotherapeutic agents.

AB - Adriamycin was paired with 12 other chemotherapeutic drugs in a search for possible synergistic pairs. Cell lethality was investigated by the colony formation method utilizing a long term human lymphoma cell line. Additive effects were noted with CCNU, ara C, prednisolone, DDP, VP 16 and Yoshi, and mild synergistic effects with BLEO and CS. Adriamycin reduced the killing ability of BCNU and MeCCNU when applied simultaneously. This antagonistic effect was canceled by sequential incubation with each drug. It appears that no significant synergism can be expected by simultaneous pairing of adriamycin with some currently available chemotherapeutic agents.

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Combination chemotherapy in vitro with adriamycin. Observations of additive, antagonistic, and synergistic effects when used in two drug combinations on cultured human lymphoma cells

Abstract

ASJC Scopus subject areas

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