Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

Dimitrios P. Kontoyiannis; Russell E. Lewis; Nir Osherov; Nathaniel D. Albert; Gregory S. May

doi:10.1093/jac/dkg090

Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

Dimitrios P. Kontoyiannis, Russell E. Lewis, Nir Osherov, Nathaniel D. Albert, Gregory S. May

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.

Original language	English (US)
Pages (from-to)	313-316
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	51
Issue number	2
DOIs	https://doi.org/10.1093/jac/dkg090
State	Published - Feb 1 2003

Keywords

Calcineurin inhibitors
Caspofungin

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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10.1093/jac/dkg090

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title = "Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species",

abstract = "Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.",

keywords = "Calcineurin inhibitors, Caspofungin",

author = "Kontoyiannis, {Dimitrios P.} and Lewis, {Russell E.} and Nir Osherov and Albert, {Nathaniel D.} and May, {Gregory S.}",

note = "Funding Information: This work was supported by the Cancer Center (Core) Grant CA16672 awarded to D.P.K. by The University of Texas M.D. Anderson Cancer Center.",

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T1 - Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

AU - Kontoyiannis, Dimitrios P.

AU - Lewis, Russell E.

AU - Osherov, Nir

AU - Albert, Nathaniel D.

AU - May, Gregory S.

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PY - 2003/2/1

Y1 - 2003/2/1

N2 - Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.

AB - Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.

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KW - Caspofungin

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Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

Abstract

Keywords

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