TY - JOUR
T1 - Combined high-grade basal cell carcinoma and malignant melanoma of the skin ("malignant basomelanocytic tumor")
T2 - Report of two coses and review of the literature
AU - Rodriguez, Jaime
AU - Nonaka, Daisuke
AU - Kuhn, Elisabetta
AU - Reichel, Martin
AU - Rosai, Juan
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/8
Y1 - 2005/8
N2 - We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high-grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB-45, MART-1, Melan-A, S100-protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.
AB - We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high-grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB-45, MART-1, Melan-A, S100-protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.
KW - Basal cell carcinoma
KW - Bidirectional differentiation
KW - Collision tumor
KW - Malignant basomelanocytic tumor
KW - Malignant melanoma
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U2 - 10.1097/01.dad.0000171600.17692.65
DO - 10.1097/01.dad.0000171600.17692.65
M3 - Review article
C2 - 16121052
AN - SCOPUS:24144470044
SN - 0193-1091
VL - 27
SP - 314
EP - 318
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 4
ER -