Common 5p15.33 and 6p21.33 variants influence lung cancer risk

Yufei Wang; Peter Broderick; Emily Webb; Xifeng Wu; Jayaram Vijayakrishnan; Athena Matakidou; Mobshra Qureshi; Qiong Dong; Xiangjun Gu; Wei Vivien Chen; Margaret R. Spitz; Timothy Eisen; Christopher I. Amos; Richard S. Houlston

doi:10.1038/ng.273

Common 5p15.33 and 6p21.33 variants influence lung cancer risk

Yufei Wang, Peter Broderick, Emily Webb, Xifeng Wu, Jayaram Vijayakrishnan, Athena Matakidou, Mobshra Qureshi, Qiong Dong, Xiangjun Gu, Wei Vivien Chen, Margaret R. Spitz, Timothy Eisen, Christopher I. Amos, Richard S. Houlston

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Abstract

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 × 10 ^-12), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P_combined = 4.97 × 10^-10) and 5p15.33 (rs401681, CLPTM1L; P_combined = 7.90 × 10^-9).

Original language	English (US)
Pages (from-to)	1407-1409
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	12
DOIs	https://doi.org/10.1038/ng.273
State	Published - Dec 2008

ASJC Scopus subject areas

Genetics

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@article{2657918762e3459e8c215d94f76b6bb7,

title = "Common 5p15.33 and 6p21.33 variants influence lung cancer risk",

abstract = "We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 × 10 -12), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; Pcombined = 4.97 × 10-10) and 5p15.33 (rs401681, CLPTM1L; Pcombined = 7.90 × 10-9).",

author = "Yufei Wang and Peter Broderick and Emily Webb and Xifeng Wu and Jayaram Vijayakrishnan and Athena Matakidou and Mobshra Qureshi and Qiong Dong and Xiangjun Gu and Chen, {Wei Vivien} and Spitz, {Margaret R.} and Timothy Eisen and Amos, {Christopher I.} and Houlston, {Richard S.}",

note = "Funding Information: Cancer Research UK (A1298/A8780) provided principal funding for this study. Additional funding was provided by HEAL and Sanofi-Aventis and US NIH Grants P50CA70907, R01CA121197 and R01CA133996. We would like to thank all individuals who participated in this study. We are grateful to colleagues at UK Clinical Genetics Centres and the UK National Cancer Research Network.",

year = "2008",

month = dec,

doi = "10.1038/ng.273",

language = "English (US)",

volume = "40",

pages = "1407--1409",

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issn = "1061-4036",

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AU - Wang, Yufei

AU - Broderick, Peter

AU - Webb, Emily

AU - Wu, Xifeng

AU - Vijayakrishnan, Jayaram

AU - Matakidou, Athena

AU - Qureshi, Mobshra

AU - Dong, Qiong

AU - Gu, Xiangjun

AU - Chen, Wei Vivien

AU - Spitz, Margaret R.

AU - Eisen, Timothy

AU - Amos, Christopher I.

AU - Houlston, Richard S.

N1 - Funding Information: Cancer Research UK (A1298/A8780) provided principal funding for this study. Additional funding was provided by HEAL and Sanofi-Aventis and US NIH Grants P50CA70907, R01CA121197 and R01CA133996. We would like to thank all individuals who participated in this study. We are grateful to colleagues at UK Clinical Genetics Centres and the UK National Cancer Research Network.

PY - 2008/12

Y1 - 2008/12

N2 - We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 × 10 -12), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; Pcombined = 4.97 × 10-10) and 5p15.33 (rs401681, CLPTM1L; Pcombined = 7.90 × 10-9).

AB - We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 × 10 -12), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; Pcombined = 4.97 × 10-10) and 5p15.33 (rs401681, CLPTM1L; Pcombined = 7.90 × 10-9).

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Common 5p15.33 and 6p21.33 variants influence lung cancer risk

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