Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer

Marc Henrion; Matthew Frampton; Ghislaine Scelo; Mark Purdue; Yuanqing Ye; Peter Broderick; Alastair Ritchie; Richard Kaplan; Angela Meade; James Mckay; Mattias Johansson; Mark Lathrop; James Larkin; Nathaniel Rothman; Zhaoming Wang; Wong Ho Chow; Victoria L. Stevens; W. Ryan Diver; Susan M. Gapstur; Demetrius Albanes; Jarmo Virtamo; Xifeng Wu; Paul Brennan; Stephen Chanock; Timothy Eisen; Richard S. Houlston

doi:10.1093/hmg/dds489

Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer

Marc Henrion, Matthew Frampton, Ghislaine Scelo, Mark Purdue, Yuanqing Ye, Peter Broderick, Alastair Ritchie, Richard Kaplan, Angela Meade, James Mckay, Mattias Johansson, Mark Lathrop, James Larkin, Nathaniel Rothman, Zhaoming Wang, Wong Ho Chow, Victoria L. Stevens, W. Ryan Diver, Susan M. Gapstur, Demetrius AlbanesJarmo Virtamo, Xifeng Wu, Paul Brennan, Stephen Chanock, Timothy Eisen, Richard S. Houlston

Epidemiology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Genome-wide association studies (GWASs) of renal cell cancer (RCC) have identified four susceptibility loci thus far. To identify an additional RCC common susceptibility locus, we conducted a GWAS and performed a meta-analysis with published GWASs (totalling 2215 cases and 8566 controls of European background) and followed up the most significant association signals [nine single nucleotide polymorphisms (SNPs) in eight genomic regions] in 3739 cases and 8786 controls. A combined analysis identified a novel susceptibility locus mapping to 2q22.3 marked by rs12105918 (P = 1.80 × 10^-8; odds ratio 1.29, 95% CI: 1.18-1.41). The signal localizes to intron 2 of the ZEB2 gene (zinc finger E box-binding homeobox 2). Our findings suggest that genetic variation in ZEB2 influences the risk of RCC. This finding provides further insights into the genetic and biological basis of inherited genetic susceptibility to RCC.

Original language	English (US)
Pages (from-to)	825-831
Number of pages	7
Journal	Human molecular genetics
Volume	22
Issue number	4
DOIs	https://doi.org/10.1093/hmg/dds489
State	Published - Feb 2013

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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Henrion, M., Frampton, M., Scelo, G., Purdue, M., Ye, Y., Broderick, P., Ritchie, A., Kaplan, R., Meade, A., Mckay, J., Johansson, M., Lathrop, M., Larkin, J., Rothman, N., Wang, Z., Chow, W. H., Stevens, V. L., Ryan Diver, W., Gapstur, S. M., ... Houlston, R. S. (2013). Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer. Human molecular genetics, 22(4), 825-831. https://doi.org/10.1093/hmg/dds489

Henrion, M, Frampton, M, Scelo, G, Purdue, M, Ye, Y, Broderick, P, Ritchie, A, Kaplan, R, Meade, A, Mckay, J, Johansson, M, Lathrop, M, Larkin, J, Rothman, N, Wang, Z, Chow, WH, Stevens, VL, Ryan Diver, W, Gapstur, SM, Albanes, D, Virtamo, J, Wu, X, Brennan, P, Chanock, S, Eisen, T & Houlston, RS 2013, 'Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer', Human molecular genetics, vol. 22, no. 4, pp. 825-831. https://doi.org/10.1093/hmg/dds489

@article{df56fdb442584782adb2abe360e7dfc7,

title = "Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer",

abstract = "Genome-wide association studies (GWASs) of renal cell cancer (RCC) have identified four susceptibility loci thus far. To identify an additional RCC common susceptibility locus, we conducted a GWAS and performed a meta-analysis with published GWASs (totalling 2215 cases and 8566 controls of European background) and followed up the most significant association signals [nine single nucleotide polymorphisms (SNPs) in eight genomic regions] in 3739 cases and 8786 controls. A combined analysis identified a novel susceptibility locus mapping to 2q22.3 marked by rs12105918 (P = 1.80 × 10-8; odds ratio 1.29, 95% CI: 1.18-1.41). The signal localizes to intron 2 of the ZEB2 gene (zinc finger E box-binding homeobox 2). Our findings suggest that genetic variation in ZEB2 influences the risk of RCC. This finding provides further insights into the genetic and biological basis of inherited genetic susceptibility to RCC.",

author = "Marc Henrion and Matthew Frampton and Ghislaine Scelo and Mark Purdue and Yuanqing Ye and Peter Broderick and Alastair Ritchie and Richard Kaplan and Angela Meade and James Mckay and Mattias Johansson and Mark Lathrop and James Larkin and Nathaniel Rothman and Zhaoming Wang and Chow, {Wong Ho} and Stevens, {Victoria L.} and {Ryan Diver}, W. and Gapstur, {Susan M.} and Demetrius Albanes and Jarmo Virtamo and Xifeng Wu and Paul Brennan and Stephen Chanock and Timothy Eisen and Houlston, {Richard S.}",

note = "Funding Information: SORCE is coordinated by the Medical Research Council (MRC) and funded principally by the MRC and Cancer Research UK with an educational grant from Bayer. Additional funding was provided by Cancer Research UK (C1298/ A8362 supported by the Bobby Moore Fund). Marc Henrion was supported by Leukaemia Lymphoma Research. NHS funding for the Royal Marsden Biomedical Research Centre and Cambridge University Health Partners is acknowledged. Funding for the SEARCH team was provided by Cancer Research UK (C490/A10124). The US kidney GWAS was funded by the Intramural Research Program of the National Cancer Institute, NIH.",

year = "2013",

month = feb,

doi = "10.1093/hmg/dds489",

language = "English (US)",

volume = "22",

pages = "825--831",

journal = "Human molecular genetics",

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T1 - Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer

AU - Henrion, Marc

AU - Frampton, Matthew

AU - Scelo, Ghislaine

AU - Purdue, Mark

AU - Ye, Yuanqing

AU - Broderick, Peter

AU - Ritchie, Alastair

AU - Kaplan, Richard

AU - Meade, Angela

AU - Mckay, James

AU - Johansson, Mattias

AU - Lathrop, Mark

AU - Larkin, James

AU - Rothman, Nathaniel

AU - Wang, Zhaoming

AU - Chow, Wong Ho

AU - Stevens, Victoria L.

AU - Ryan Diver, W.

AU - Gapstur, Susan M.

AU - Albanes, Demetrius

AU - Virtamo, Jarmo

AU - Wu, Xifeng

AU - Brennan, Paul

AU - Chanock, Stephen

AU - Eisen, Timothy

AU - Houlston, Richard S.

N1 - Funding Information: SORCE is coordinated by the Medical Research Council (MRC) and funded principally by the MRC and Cancer Research UK with an educational grant from Bayer. Additional funding was provided by Cancer Research UK (C1298/ A8362 supported by the Bobby Moore Fund). Marc Henrion was supported by Leukaemia Lymphoma Research. NHS funding for the Royal Marsden Biomedical Research Centre and Cambridge University Health Partners is acknowledged. Funding for the SEARCH team was provided by Cancer Research UK (C490/A10124). The US kidney GWAS was funded by the Intramural Research Program of the National Cancer Institute, NIH.

PY - 2013/2

Y1 - 2013/2

N2 - Genome-wide association studies (GWASs) of renal cell cancer (RCC) have identified four susceptibility loci thus far. To identify an additional RCC common susceptibility locus, we conducted a GWAS and performed a meta-analysis with published GWASs (totalling 2215 cases and 8566 controls of European background) and followed up the most significant association signals [nine single nucleotide polymorphisms (SNPs) in eight genomic regions] in 3739 cases and 8786 controls. A combined analysis identified a novel susceptibility locus mapping to 2q22.3 marked by rs12105918 (P = 1.80 × 10-8; odds ratio 1.29, 95% CI: 1.18-1.41). The signal localizes to intron 2 of the ZEB2 gene (zinc finger E box-binding homeobox 2). Our findings suggest that genetic variation in ZEB2 influences the risk of RCC. This finding provides further insights into the genetic and biological basis of inherited genetic susceptibility to RCC.

AB - Genome-wide association studies (GWASs) of renal cell cancer (RCC) have identified four susceptibility loci thus far. To identify an additional RCC common susceptibility locus, we conducted a GWAS and performed a meta-analysis with published GWASs (totalling 2215 cases and 8566 controls of European background) and followed up the most significant association signals [nine single nucleotide polymorphisms (SNPs) in eight genomic regions] in 3739 cases and 8786 controls. A combined analysis identified a novel susceptibility locus mapping to 2q22.3 marked by rs12105918 (P = 1.80 × 10-8; odds ratio 1.29, 95% CI: 1.18-1.41). The signal localizes to intron 2 of the ZEB2 gene (zinc finger E box-binding homeobox 2). Our findings suggest that genetic variation in ZEB2 influences the risk of RCC. This finding provides further insights into the genetic and biological basis of inherited genetic susceptibility to RCC.

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JO - Human molecular genetics

JF - Human molecular genetics

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ER -

Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer

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