Comparative efficacy of central venous cathetcbs impregnated wtth mdfocvcune and bifampin vs catheters impregnated wtth chlorhkxidine glüconate and silver sulfadiazine: A prospective, randomized, multicxnter clinical trial

latndactioK AntimkrobUl arntjag al central venous catbeten (CVC) either with minocydine and ri&mpin (M/R) or with chlorhezidine ghcramr and silver fm. (CXVSS) was reported to redoce the rates at both catheter coloniratioo (CQ and catheter-idated bloodsbtam iafectiaa (CRBSI) (Am Imttrm Utd. 1997:127:257.274). We andertook this baft, prospective, randomized, multicenter dinical trial to compare the rates of CC and CRBSI between CVC impregnated with M/R vs CVC impiesjttated with CG/SS. CVC for > 3 days were of to receive CVC M/R or CG/SS. Upon catheter removal, the subcutaneous and tip segmena were cuitared usiat both roll-plate and lonication trrhniqnr. ResMbK Ofa total of S65 inserted CVC, 743 (S5.9%) were cultured and considered evataable (357 CVC impregMsed with M/R vs 316 CVC impregnated with CG/SS). Patients and CVC in aw two groups were infection. CVC impregnated with M/R were three-fcJd test Hkdy to be colonized <> 13 cb by raO plate and/or > 1.000 era by somcatioa) than CVC impregnated with CG/SS (28/357-7.% vsf7/3J6- 22.6 %; p < 0.0001) and were twdve-fidd less likely to produce CRBSI (1/357 - OJ% vs 13/3S6 3.4%; <0.002X No advene effects from either CVC were observed. Conclusions: CVC T1 M/R are -pHtrty mperior to CVC nptgpn with CG/SS in their antiinfective efficacy.