TY - JOUR
T1 - Comparative studies of prostate cancers among United States, Chinese, and Japanese patients
T2 - characterization of histopathology, tumor angiogenesis, neuroendocrine factors, and p53 protein accumulations
AU - Zhau, Haiyen E.
AU - Zhao, Lian Sheng
AU - Chung, Leland W.K.
AU - Chen, Bao Qi
AU - Troncoso, Patricia
AU - Kao, Chinghai
AU - Kojima, Munekado
AU - Fraser Symmans, W.
AU - Zheng, Ninjia
AU - Palmer, Judy L.
AU - Moul, Judd W.
AU - Davis, Rodney
AU - Ye, Ming Fu
AU - Xiao, Lian Sheng
AU - Craig Hall, M.
N1 - Funding Information:
This study was supported by NIH Grant CA 57361 awarded to HYEZ. This study is dedicated to UCUR United States China Urologic Research Group, the devoted clinicians and researchers from both countries, and the founding members. Special thanks to Dr. Andrew C. van Eschenbach for his support, Dr. Ryuichi Yantani for clinical information on the Japanese prostate cancer patients, and to Dr. Gunar Zagars for multivariate analyses. We thank Carolyn Davis for her secretarial skills, Sunita Patterson for editorial assistance, and Dr. Akinobu Gotoh for translating the Japanese literature.
PY - 1995
Y1 - 1995
N2 - Although interracial differences of prostate cancer progression are well recognized, their underlying molecular and cellular mechanisms remain obscure. We compared the histopathologic, immunohistochemical, and molecular characteristics of unselected prostate cancer tissues obtained from U.S., Chinese, and Japanese men. Histopathologic analyses indicated that 74.4% of the prostate cancers in Chinese men were poorly differentiated, compared with 28.6% and 32.8% of the prostate cancers in U.S. and Japanese men, respectively. These differences cannot be attributed to patient age, clinical stage of disease, or methods of tissue sampling. The high proportion of poorly differentiated prostate cancer tissues in the Chinese group was not related to the patients' access to medical service or to geographic background within China. Significantly higher levels of tumor angiogenesis (2- to 4-fold), serotonin (2- to 20-fold), and bombesin (7- to 16-fold), but not chromogranin A, were found in the tissue specimens obtained from Chinese prostate cancer patients compared with those from U.S. and Japanese patients. We also observed marked interracial differences in p53 protein accumulation. The protein was present in 90.2% of Chinese specimens; 17.4% of specimens from U.S. whites; 7.1% of specimens from Japanese men; and 3.7% of specimens from U.S. blacks. Results from multivariate logistic regression analysis demonstrated that p53 protein accumulation, angiogenesis, and serotonin expression in the normal stroma area correlate independently with Chinese versus non-Chinese patient populations.
AB - Although interracial differences of prostate cancer progression are well recognized, their underlying molecular and cellular mechanisms remain obscure. We compared the histopathologic, immunohistochemical, and molecular characteristics of unselected prostate cancer tissues obtained from U.S., Chinese, and Japanese men. Histopathologic analyses indicated that 74.4% of the prostate cancers in Chinese men were poorly differentiated, compared with 28.6% and 32.8% of the prostate cancers in U.S. and Japanese men, respectively. These differences cannot be attributed to patient age, clinical stage of disease, or methods of tissue sampling. The high proportion of poorly differentiated prostate cancer tissues in the Chinese group was not related to the patients' access to medical service or to geographic background within China. Significantly higher levels of tumor angiogenesis (2- to 4-fold), serotonin (2- to 20-fold), and bombesin (7- to 16-fold), but not chromogranin A, were found in the tissue specimens obtained from Chinese prostate cancer patients compared with those from U.S. and Japanese patients. We also observed marked interracial differences in p53 protein accumulation. The protein was present in 90.2% of Chinese specimens; 17.4% of specimens from U.S. whites; 7.1% of specimens from Japanese men; and 3.7% of specimens from U.S. blacks. Results from multivariate logistic regression analysis demonstrated that p53 protein accumulation, angiogenesis, and serotonin expression in the normal stroma area correlate independently with Chinese versus non-Chinese patient populations.
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U2 - 10.1016/1078-1439(95)00009-7
DO - 10.1016/1078-1439(95)00009-7
M3 - Article
C2 - 21224092
AN - SCOPUS:0003935701
SN - 1078-1439
VL - 1
SP - 51
EP - 63
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
IS - 2
ER -