TY - JOUR
T1 - Comparison of a CMOS-based and a CCD-based digital x-ray imaging system
T2 - Observer studies
AU - Zhang, Qirong
AU - Li, Yuhua
AU - Steele, Ben
AU - Wu, Xiseng
AU - Chen, Wei R.
AU - Rong, John
AU - Liu, Hong
N1 - Funding Information:
This work was supported in part by grants from the National Institute of Health (CA70209) and from DoD breast cancer research grants (DAMD17-97-1-7138, and DAMD17-01-1-0539), by a grant from the Dr. Jackson College of Graduate Studies and Research of the University of Central Oklahoma, by a grant from the National Institute of Health (P20 RR016478 from the INBRE Program of the National Center for Research Resources), and by a grant from the Oklahoma Center for the Advancement of Science and Technology (OCAST) (AP01-016).
PY - 2005/4
Y1 - 2005/4
N2 - The purpose of this study is to compare the performance of a complementary metal-oxide-semiconductor (CMOS)-based digital x-ray imaging system with that of a charge-coupled device (CCD)-based system for small animal research. A CMOS-based digital x-ray imaging system was developed and tested. The core of this system is a detector module consisting of eight joint CMOS chips, each having a size of 512×1024 pixels with a readout unit on the side. The pixel size of the CMOS detectors is 0.048 mm. The contrast detail detectability of the CMOS-based system was studied using different phantoms, and compared with that of a CCD-based digital imaging system. The contrast detail curves of the CMOS-based image system, obtained from the observer-based studies, are highly comparable to the CCD-based imaging system, particularly at higher x-ray exposures. The images of fine structures of a mouse, acquired by the CMOS system, demonstrated the capability of the system in the studies of small animals. With integration potential, manufacturability, and low costs, the CMOS-based imaging systems could be used in animal studies and potentially become useful clinical tools for diagnosis.
AB - The purpose of this study is to compare the performance of a complementary metal-oxide-semiconductor (CMOS)-based digital x-ray imaging system with that of a charge-coupled device (CCD)-based system for small animal research. A CMOS-based digital x-ray imaging system was developed and tested. The core of this system is a detector module consisting of eight joint CMOS chips, each having a size of 512×1024 pixels with a readout unit on the side. The pixel size of the CMOS detectors is 0.048 mm. The contrast detail detectability of the CMOS-based system was studied using different phantoms, and compared with that of a CCD-based digital imaging system. The contrast detail curves of the CMOS-based image system, obtained from the observer-based studies, are highly comparable to the CCD-based imaging system, particularly at higher x-ray exposures. The images of fine structures of a mouse, acquired by the CMOS system, demonstrated the capability of the system in the studies of small animals. With integration potential, manufacturability, and low costs, the CMOS-based imaging systems could be used in animal studies and potentially become useful clinical tools for diagnosis.
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U2 - 10.1117/1.1902763
DO - 10.1117/1.1902763
M3 - Article
AN - SCOPUS:23444448426
SN - 1017-9909
VL - 14
SP - 1
EP - 6
JO - Journal of Electronic Imaging
JF - Journal of Electronic Imaging
IS - 2
M1 - 023002
ER -