TY - JOUR
T1 - Comparison of outcomes in patients with early-stage mucinous endometrial cancer and those with endometrioid endometrial cancer, with and without adjuvant therapy
AU - Owusu-Darko, Sharon
AU - Rauh-Hain, J. Alejandro
AU - Horowitz, Neil S.
AU - Goodman, Annekathryn
AU - Schorge, John O.
AU - del Carmen, Marcela G.
N1 - Publisher Copyright:
© Journal of Reproductive Medicine®, Inc.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - OBJECTIVE: To compare risk factors, treatment, and outcomes in patients with stage I/II mucinous endometrial cancer (MEC) relative to those of patients with endometrioid endometrial cancer (EEC). STUDY DESIGN: We conducted a case-control study of patients with MEC and EEC. Patients with stage IA, IB, or II MEC treated at the 2 institutions between 01/01/ 1996 and 01/01/2007 were identified. Each MEC case was matched with 2 EEC controls by age, stage, grade, and year of diagnosis. The Kaplan-Meier method was used to generate overall survival (OS) data. Factors predictive of outcome were compared using the log-rank test and Cox proportional hazards model. RESULTS: A total of 34 patients with MEC were compared to 68 controls with EEC. All patients were treated by hysterectomy and bilateral salpingo-oophorectomy. Use of adjuvant radiation therapy was similar between cases and controls. The 5-year disease-free survival (DFS) rates were not significantly different in patients with MEC when compared to those with EEC (89% vs. 92%, respectively, p=0.2). The 5-year OS rates for patients with MEC and the control group were 95% and 96%, respectively (p=0.1). CONCLUSION: Patients with early-stage MEC and EEC have similar DFS and overall survival.
AB - OBJECTIVE: To compare risk factors, treatment, and outcomes in patients with stage I/II mucinous endometrial cancer (MEC) relative to those of patients with endometrioid endometrial cancer (EEC). STUDY DESIGN: We conducted a case-control study of patients with MEC and EEC. Patients with stage IA, IB, or II MEC treated at the 2 institutions between 01/01/ 1996 and 01/01/2007 were identified. Each MEC case was matched with 2 EEC controls by age, stage, grade, and year of diagnosis. The Kaplan-Meier method was used to generate overall survival (OS) data. Factors predictive of outcome were compared using the log-rank test and Cox proportional hazards model. RESULTS: A total of 34 patients with MEC were compared to 68 controls with EEC. All patients were treated by hysterectomy and bilateral salpingo-oophorectomy. Use of adjuvant radiation therapy was similar between cases and controls. The 5-year disease-free survival (DFS) rates were not significantly different in patients with MEC when compared to those with EEC (89% vs. 92%, respectively, p=0.2). The 5-year OS rates for patients with MEC and the control group were 95% and 96%, respectively (p=0.1). CONCLUSION: Patients with early-stage MEC and EEC have similar DFS and overall survival.
KW - Endometrial cancer
KW - Endometrioid endometrial cancer
KW - Gynecological malignancies
KW - Hyperestrogenism
KW - Mucinous endometrial cancer
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M3 - Article
C2 - 25552123
AN - SCOPUS:84925224280
SN - 0024-7758
VL - 59
SP - 527
EP - 533
JO - Journal of Reproductive Medicine
JF - Journal of Reproductive Medicine
IS - 6
ER -