TY - JOUR
T1 - Comparison of prediction equations to estimate glomerular filtration rate in Chinese patients with chronic kidney disease
AU - Liu, X.
AU - Lv, L.
AU - Wang, C.
AU - Shi, C.
AU - Cheng, C.
AU - Tang, H.
AU - Chen, Z.
AU - Ye, Z.
AU - Lou, T.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/5
Y1 - 2012/5
N2 - Aim: We sought to evaluate the applicability of formulae based on serum creatinine (SC) levels in Chinese patients with chronic kidney disease (CKD). Materials and methods: Three hundred and twenty-seven patients with CKD who had undergone 99mTc-DTPA glomerular filtration rate (GFR) estimation were enrolled. The Cockcroft-Gault equation, SC-reciprocal equation, Gate equation, Hull equation, Jelliffe-1973 equation, Jelliffe-1971 equation, Mawer equation, Bjornsson equation, reexpressed 6-variable MDRD equation and reexpressed 4-variable MDRD equation were compared. Using the 99mTc-DTPA GFR as the standard GFR (sGFR), the accuracy of estimated GFR was compared with sGFR in various stages of CKD. Results: Median per cents of the absolute difference ranged from 28.16% to 39.39%, accuracy with a deviation less than 30% ranging from 39.4% to 53.5%, accuracy with a deviation less than 50% ranging from 63.0% to 80.7%. None of the equations had accuracy up to the 70% level with a deviation less than 30% from sGFR. Bland-Altman analysis demonstrated that mean difference ranged from -2.42 to 16.39mL/min/1.73m2, whereas precision ranged from 82.66 to 106.15mL/min/1.73m2. However, the agreement limits of all the equations exceeded the prior acceptable tolerances defined as 60mL/min/1.73m2. Linear regression showed that the slopes of regression line ranged from 0.37 to 0.54 and intercepts ranged from -12.10 to 3.86. When the overall performance as well as bias and accuracy were compared in different stages of CKD, GFR estimated by Jelliffe-1973 equation, Cockcroft-Gault equation and Bjornsson equation showed promising results. Conclusion: When SC was measured by the enzymatic method, GFR estimation equations showed great bias in Chinese CKD patients. At present, the Jelliffe-1973 equation and Cockcroft-Gault equation may be more accurate in the Chinese ethnic group.
AB - Aim: We sought to evaluate the applicability of formulae based on serum creatinine (SC) levels in Chinese patients with chronic kidney disease (CKD). Materials and methods: Three hundred and twenty-seven patients with CKD who had undergone 99mTc-DTPA glomerular filtration rate (GFR) estimation were enrolled. The Cockcroft-Gault equation, SC-reciprocal equation, Gate equation, Hull equation, Jelliffe-1973 equation, Jelliffe-1971 equation, Mawer equation, Bjornsson equation, reexpressed 6-variable MDRD equation and reexpressed 4-variable MDRD equation were compared. Using the 99mTc-DTPA GFR as the standard GFR (sGFR), the accuracy of estimated GFR was compared with sGFR in various stages of CKD. Results: Median per cents of the absolute difference ranged from 28.16% to 39.39%, accuracy with a deviation less than 30% ranging from 39.4% to 53.5%, accuracy with a deviation less than 50% ranging from 63.0% to 80.7%. None of the equations had accuracy up to the 70% level with a deviation less than 30% from sGFR. Bland-Altman analysis demonstrated that mean difference ranged from -2.42 to 16.39mL/min/1.73m2, whereas precision ranged from 82.66 to 106.15mL/min/1.73m2. However, the agreement limits of all the equations exceeded the prior acceptable tolerances defined as 60mL/min/1.73m2. Linear regression showed that the slopes of regression line ranged from 0.37 to 0.54 and intercepts ranged from -12.10 to 3.86. When the overall performance as well as bias and accuracy were compared in different stages of CKD, GFR estimated by Jelliffe-1973 equation, Cockcroft-Gault equation and Bjornsson equation showed promising results. Conclusion: When SC was measured by the enzymatic method, GFR estimation equations showed great bias in Chinese CKD patients. At present, the Jelliffe-1973 equation and Cockcroft-Gault equation may be more accurate in the Chinese ethnic group.
KW - Chinese
KW - Chronic
KW - Equation
KW - Glomerular filtration rate
KW - Kidney disease
KW - Serum creatinine
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U2 - 10.1111/j.1445-5994.2010.02398.x
DO - 10.1111/j.1445-5994.2010.02398.x
M3 - Article
C2 - 21118405
AN - SCOPUS:84861425446
SN - 1444-0903
VL - 42
SP - e59-e67
JO - Internal Medicine Journal
JF - Internal Medicine Journal
IS - 5
ER -