@article{03fee94466a144c9ac12d00321e3ea0c,
title = "Computed Tomography Radiomics Kinetics as Early Imaging Correlates of Osteoradionecrosis in Oropharyngeal Cancer Patients",
abstract = "Osteoradionecrosis (ORN) is a major side-effect of radiation therapy in oropharyngeal cancer (OPC) patients. In this study, we demonstrate that early prediction of ORN is possible by analyzing the temporal evolution of mandibular subvolumes receiving radiation. For our analysis, we use computed tomography (CT) scans from 21 OPC patients treated with Intensity Modulated Radiation Therapy (IMRT) with subsequent radiographically-proven ≥ grade II ORN, at three different time points: pre-IMRT, 2-months, and 6-months post-IMRT. For each patient, radiomic features were extracted from a mandibular subvolume that developed ORN and a control subvolume that received the same dose but did not develop ORN. We used a Multivariate Functional Principal Component Analysis (MFPCA) approach to characterize the temporal trajectories of these features. The proposed MFPCA model performs the best at classifying ORN vs. Control subvolumes with an area under curve (AUC) = 0.74 [95% confidence interval (C.I.): 0.61–0.90], significantly outperforming existing approaches such as a pre-IMRT features model or a delta model based on changes at intermediate time points, i.e., at 2- and 6-month follow-up. This suggests that temporal trajectories of radiomics features derived from sequential pre- and post-RT CT scans can provide markers that are correlates of RT-induced mandibular injury, and consequently aid in earlier management of ORN.",
keywords = "computed tomography, functional principal component analysis, head and neck cancer, longitudinal, oropharyngeal cancer, osteoradionecrosis, radiomics, radiotherapy",
author = "Souptik Barua and Hesham Elhalawani and Stefania Volpe and {Al Feghali}, {Karine A.} and Pei Yang and Ng, {Sweet Ping} and Baher Elgohari and Granberry, {Robin C.} and Mackin, {Dennis S.} and Gunn, {G. Brandon} and Hutcheson, {Katherine A.} and Chambers, {Mark S.} and Court, {Laurence E.} and Mohamed, {Abdallah S.R.} and Fuller, {Clifton D.} and Lai, {Stephen Y.} and Arvind Rao",
note = "Funding Information: SB and AR were supported by CCSG Bioinformatics Shared Resource P30 CA016672, CPRIT RP170719, CPRIT RP150578, NCI 1R37CA214955-01A1, a gift from Agilent technologies, and a Research Scholar Grant from the American Cancer Society (RSG-16-005-01). AR was a member of Voxel Analytics, LLC, reports receiving other commercial research support from Agilent Technologies. HE was supported in part by the philanthropic donations from the Family of Paul W. Beach to GG, HE, and CF receive funding and project-relevant salary support from NIH/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Award (P50 CA097007-10). This research was supported by the Andrew Sabin Family Foundation; CF was a Sabin Family Foundation Fellow. CF, SL, and AM receive funding and project-relevant salary support from the National Institutes of Health (NIH), including: National Institute for Dental and Craniofacial Research Award (1R01DE025248-01/R56DE025248-01). CF, SL, KH, and AM receive funding and project-relevant salary support from NCI Early Phase Clinical Trials in Imaging and Image-Guided Interventions Program (1R01CA218148-01). CF and AM receive funding and project-relevant salary support from National Science Foundation (NSF), Division of Mathematical Sciences, Joint NIH/NSF Initiative on Quantitative Approaches to Biomedical Big Data (QuBBD) Grant (NSF 1557679); NIH Big Data to Knowledge (BD2K) Program of the National Cancer Institute Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science Award (1R01CA214825-01). CF receive funding and project-relevant salary support from NIH/NCI Cancer Center Support Grant (CCSG) Pilot Research Program Award from the UT MD Anderson CCSG Radiation Oncology and Cancer Imaging Program (P30CA016672) and National Institute of Biomedical Imaging and Bioengineering (NIBIB) Research Education Program (R25EB025787). CF has received direct industry grant support and travel funding from Elekta AB. AM was funded for this work by The University of Texas MD Anderson Cancer Center-Oropharynx Cancer Program generously supported by Mr. and Mrs. Charles W. Stiefel. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Barua, Elhalawani, Volpe, Al Feghali, Yang, Ng, Elgohari, Granberry, Mackin, Gunn, Hutcheson, Chambers, Court, Mohamed, Fuller, Lai and Rao.",
year = "2021",
month = apr,
day = "9",
doi = "10.3389/frai.2021.618469",
language = "English (US)",
volume = "4",
journal = "Frontiers in Artificial Intelligence",
issn = "2624-8212",
publisher = "Frontiers Media S. A.",
}