TY - JOUR
T1 - Concise review
T2 - Umbilical cord blood transplantation: Past, present, and future
AU - Munoz, Javier
AU - Shah, Nina
AU - Rezvani, Katayoun
AU - Hosing, Chitra
AU - Bollard, Catherine M.
AU - Oran, Betul
AU - Olson, Amanda
AU - Popat, Uday
AU - Molldrem, Jeffrey
AU - McNiece, Ian K.
AU - Shpall, Elizabeth J.
N1 - Publisher Copyright:
©AlphaMed Press 2014.
PY - 2014
Y1 - 2014
N2 - Allogeneic hematopoietic stem cell transplantation is an important treatment option for fit patients with poor-risk hematological malignancies; nevertheless, the lack of available fully matched donors limits the extent of its use. Umbilical cord blood has emerged as an effective alternate source of hematopoietic stem cell support. Transplantation with cord blood allows for faster availability of frozen sample and avoids invasive procedures for donors. In addition, this procedure has demonstrated reduced relapse rates and similar overall survival when compared with unrelated allogeneic hematopoietic stem cell transplantation. The limited dose of CD34-positive stem cells available with single-unit cord transplantation has been addressed by the development of double-unit cord transplantation. In combination with improved conditioning regimens, double-unit cord transplantation has allowed for the treatment of larger children, as well as adult patients with hematological malignancies. Current excitement in the field revolves around the development of safer techniques to improve homing, engraftment, and immune reconstitution after cord blood transplantation. Here the authors review the past, present, and future of cord transplantation.
AB - Allogeneic hematopoietic stem cell transplantation is an important treatment option for fit patients with poor-risk hematological malignancies; nevertheless, the lack of available fully matched donors limits the extent of its use. Umbilical cord blood has emerged as an effective alternate source of hematopoietic stem cell support. Transplantation with cord blood allows for faster availability of frozen sample and avoids invasive procedures for donors. In addition, this procedure has demonstrated reduced relapse rates and similar overall survival when compared with unrelated allogeneic hematopoietic stem cell transplantation. The limited dose of CD34-positive stem cells available with single-unit cord transplantation has been addressed by the development of double-unit cord transplantation. In combination with improved conditioning regimens, double-unit cord transplantation has allowed for the treatment of larger children, as well as adult patients with hematological malignancies. Current excitement in the field revolves around the development of safer techniques to improve homing, engraftment, and immune reconstitution after cord blood transplantation. Here the authors review the past, present, and future of cord transplantation.
KW - Graft versus host disease
KW - Hematopoietic stem cell transplantation
KW - Leukemia
KW - Lymphoma
KW - Transplant related mortality
KW - Umbilical cord blood transplantation
UR - http://www.scopus.com/inward/record.url?scp=84913570653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84913570653&partnerID=8YFLogxK
U2 - 10.5966/sctm.2014-0151
DO - 10.5966/sctm.2014-0151
M3 - Article
C2 - 25378655
AN - SCOPUS:84913570653
SN - 2157-6564
VL - 3
SP - 1435
EP - 1443
JO - Stem Cells Translational Medicine
JF - Stem Cells Translational Medicine
IS - 12
ER -