TY - JOUR
T1 - Congenital peribronchial myofibroblastic tumor (so-called "congenital leiomyosarcoma"). A distinct neonatal lung lesion associated with nonimmune hydrops fetalis.
AU - McGinnis, M.
AU - Jacobs, G.
AU - el-Naggar, A.
AU - Redline, R. W.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 1993/7
Y1 - 1993/7
N2 - An unusual solid tumor composed of myofibroblasts in an infant with nonimmune hydrops fetalis is presented together with a review of previous cases reported under a variety of different names, most notably congenital leiomyosarcoma. Immunocytochemical, ultrastructural, and flow cytometric data plus an analysis of fetal lung specimens from various times during lung development suggest that this tumor arises from the condensed mesenchyme that surrounds those respiratory ducts that go on to form large bronchi. Because of its age of onset, cellular composition, and benign biological behavior we believe that this tumor is analogous to two other congenital myofibroblastic tumors, congenital mesoblastic nephroma, and spindle cell tumor of the intestinal tract. Although the term myofibroblastoma has gained popularity in recent reports describing localized proliferations of myofibroblasts in adults, we would like to emphasize the unique developmental origin of this lesion and suggest the term congenital peribronchial myofibroblastic tumor.
AB - An unusual solid tumor composed of myofibroblasts in an infant with nonimmune hydrops fetalis is presented together with a review of previous cases reported under a variety of different names, most notably congenital leiomyosarcoma. Immunocytochemical, ultrastructural, and flow cytometric data plus an analysis of fetal lung specimens from various times during lung development suggest that this tumor arises from the condensed mesenchyme that surrounds those respiratory ducts that go on to form large bronchi. Because of its age of onset, cellular composition, and benign biological behavior we believe that this tumor is analogous to two other congenital myofibroblastic tumors, congenital mesoblastic nephroma, and spindle cell tumor of the intestinal tract. Although the term myofibroblastoma has gained popularity in recent reports describing localized proliferations of myofibroblasts in adults, we would like to emphasize the unique developmental origin of this lesion and suggest the term congenital peribronchial myofibroblastic tumor.
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M3 - Review article
C2 - 8415597
AN - SCOPUS:0027638538
SN - 0893-3952
VL - 6
SP - 487
EP - 492
JO - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
IS - 4
ER -