TY - JOUR
T1 - Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
AU - Dienstmann, Rodrigo
AU - Vermeulen, Louis
AU - Guinney, Justin
AU - Kopetz, Scott
AU - Tejpar, Sabine
AU - Tabernero, Josep
N1 - Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2017/1/27
Y1 - 2017/1/27
N2 - Critical driver genomic events in colorectal cancer have been shown to affect the response to targeted agents that were initially developed under the 'one gene, one drug' paradigm of precision medicine. Our current knowledge of the complexity of the cancer genome, clonal evolution patterns under treatment pressure and pharmacodynamic effects of target inhibition support the transition from a one gene, one drug approach to a 'multi-gene, multi-drug' model when making therapeutic decisions. Better characterization of the transcriptomic subtypes of colorectal cancer, encompassing tumour, stromal and immune components, has revealed convergent pathway dependencies that mandate a 'multi-molecular' perspective for the development of therapies to treat this disease.
AB - Critical driver genomic events in colorectal cancer have been shown to affect the response to targeted agents that were initially developed under the 'one gene, one drug' paradigm of precision medicine. Our current knowledge of the complexity of the cancer genome, clonal evolution patterns under treatment pressure and pharmacodynamic effects of target inhibition support the transition from a one gene, one drug approach to a 'multi-gene, multi-drug' model when making therapeutic decisions. Better characterization of the transcriptomic subtypes of colorectal cancer, encompassing tumour, stromal and immune components, has revealed convergent pathway dependencies that mandate a 'multi-molecular' perspective for the development of therapies to treat this disease.
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U2 - 10.1038/nrc.2016.126
DO - 10.1038/nrc.2016.126
M3 - Review article
C2 - 28050011
AN - SCOPUS:85008339326
SN - 1474-175X
VL - 17
SP - 79
EP - 92
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 2
ER -