Abstract
Progesterone priming of the ovariectomized rat, followed by a single injection of estradiol-17β (10 μg) is followed by an increased uterine synthesis of both PGF and PGE. The administration of an estrogen antagonist (MER-25; 10 mg) concomitantly with estradiol had no effect on uterine prostaglandin synthesis. Similarly, the administration of either Actinomycin D or cycloheximide, antibiotics demonstrated to inhibit mRNA and protein synthesis, respectively, is without effect on estrogen-stimulated uterine prostaglandin synthesis. These results are considered with regard to the classic receptor theory of estrogen action and are a preliminary indication that estrogen-stimulated uterine prostaglandin synthesis may not require those receptor mediated events.
Original language | English (US) |
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Pages (from-to) | 243-251 |
Number of pages | 9 |
Journal | Prostaglandins |
Volume | 12 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Endocrinology