Continuous-infusion high-dose leucovorin with 5-fluorouracil and cisplatin for relapsed metastatic breast cancer: A phase II study

Daniel J. Booser; Ronald S. Walters; Frankie A. Holmes; Gabriel N. Hortobagyi

doi:10.1097/00000421-200002000-00011

Continuous-infusion high-dose leucovorin with 5-fluorouracil and cisplatin for relapsed metastatic breast cancer: A phase II study

Daniel J. Booser, Ronald S. Walters, Frankie A. Holmes, Gabriel N. Hortobagyi

Breast Medical Oncology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Twelve women with metastatic breast cancer were treated with continuous infusion high dose leucovorin, 5-fluorouracil and cisplatin. Toxicity was severe although the dose was lower than previously described for the treatment of other cancers, and there was little anti-tumor activity. Many other regimens are more effective and less toxic.

Original language	English (US)
Pages (from-to)	40-41
Number of pages	2
Journal	American Journal of Clinical Oncology: Cancer Clinical Trials
Volume	23
Issue number	1
DOIs	https://doi.org/10.1097/00000421-200002000-00011
State	Published - Feb 2000

Keywords

5-FU
Breast cancer
Cisplatin
Leucovorin
Relapse

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1097/00000421-200002000-00011

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abstract = "Twelve women with metastatic breast cancer were treated with continuous infusion high dose leucovorin, 5-fluorouracil and cisplatin. Toxicity was severe although the dose was lower than previously described for the treatment of other cancers, and there was little anti-tumor activity. Many other regimens are more effective and less toxic.",

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AU - Walters, Ronald S.

AU - Holmes, Frankie A.

AU - Hortobagyi, Gabriel N.

PY - 2000/2

Y1 - 2000/2

N2 - Twelve women with metastatic breast cancer were treated with continuous infusion high dose leucovorin, 5-fluorouracil and cisplatin. Toxicity was severe although the dose was lower than previously described for the treatment of other cancers, and there was little anti-tumor activity. Many other regimens are more effective and less toxic.

AB - Twelve women with metastatic breast cancer were treated with continuous infusion high dose leucovorin, 5-fluorouracil and cisplatin. Toxicity was severe although the dose was lower than previously described for the treatment of other cancers, and there was little anti-tumor activity. Many other regimens are more effective and less toxic.

KW - 5-FU

KW - Breast cancer

KW - Cisplatin

KW - Leucovorin

KW - Relapse

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Continuous-infusion high-dose leucovorin with 5-fluorouracil and cisplatin for relapsed metastatic breast cancer: A phase II study

Abstract

Keywords

ASJC Scopus subject areas

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