TY - JOUR
T1 - Contrast-enhanced endoscopic ultrasonography with galactose microparticles
T2 - SHU508 A (Levovist)
AU - Bhutani, M. S.
AU - Hoffman, B. J.
AU - Van Velse, A.
AU - Hawes, R. H.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1997/9
Y1 - 1997/9
N2 - Background and Study Aims: To evaluate the utility of a suspension of galactose microparticles available as SHU508 A (Levovist) as a contrast agent during endoscopic ultrasonography (EUS). Materials and Methods: Three sets of experiments were performed on three 20-25 kg swine (Sus scrofa) under general anesthesia. Upper EUS was performed with an echo endoscope with color Doppler capability (Pentax FG-32 UA). The celiac artery, superior mesenteric artery, aorta, portal vein, pancreas, and gastrointestinal wall were imaged by EUS. Multiple intravenous bolus injections of 400 mg/ml of SHU508 A were made, and their effect on color Doppler and gray-scale imaging during EUS was studied. Results: After contrast injection there was a significant, visually noticeable enhancement of the color Doppler signals from the celiac artery superior mesenteric artery, and portal vein. Vessels with weak to no color Doppier signals before injection of SHU508 A - for example, the celiac artery and superior mesenteric artery - were observed to have strong color signals after injection. The effect of SHU508 A on color Doppler imaging was easily appreciated subjectively without the need for complex quantitative measurements. No visually noticeable color Doppler enhancement was seen in vessels such as the aorta that had a very pronounced color Doppler signal even prior to the injection of contrast. Movement of particulate matter was seen in the portal vein on the gray scale. Conclusion: Intravenous SHU508 A as a contrast agent significantly enhances color Doppler signals during EUS. Vascular contrast of this sort could potentially have a significant role in improving the accuracy of EUS in diagnosing malignant vascular invasion, the detection of occult pancreatic neoplasms, and the diagnosis of vascular thrombosis.
AB - Background and Study Aims: To evaluate the utility of a suspension of galactose microparticles available as SHU508 A (Levovist) as a contrast agent during endoscopic ultrasonography (EUS). Materials and Methods: Three sets of experiments were performed on three 20-25 kg swine (Sus scrofa) under general anesthesia. Upper EUS was performed with an echo endoscope with color Doppler capability (Pentax FG-32 UA). The celiac artery, superior mesenteric artery, aorta, portal vein, pancreas, and gastrointestinal wall were imaged by EUS. Multiple intravenous bolus injections of 400 mg/ml of SHU508 A were made, and their effect on color Doppler and gray-scale imaging during EUS was studied. Results: After contrast injection there was a significant, visually noticeable enhancement of the color Doppler signals from the celiac artery superior mesenteric artery, and portal vein. Vessels with weak to no color Doppier signals before injection of SHU508 A - for example, the celiac artery and superior mesenteric artery - were observed to have strong color signals after injection. The effect of SHU508 A on color Doppler imaging was easily appreciated subjectively without the need for complex quantitative measurements. No visually noticeable color Doppler enhancement was seen in vessels such as the aorta that had a very pronounced color Doppler signal even prior to the injection of contrast. Movement of particulate matter was seen in the portal vein on the gray scale. Conclusion: Intravenous SHU508 A as a contrast agent significantly enhances color Doppler signals during EUS. Vascular contrast of this sort could potentially have a significant role in improving the accuracy of EUS in diagnosing malignant vascular invasion, the detection of occult pancreatic neoplasms, and the diagnosis of vascular thrombosis.
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U2 - 10.1055/s-2007-1004270
DO - 10.1055/s-2007-1004270
M3 - Article
C2 - 9360874
AN - SCOPUS:0030780279
SN - 0013-726X
VL - 29
SP - 635
EP - 639
JO - Endoscopy
JF - Endoscopy
IS - 7
ER -