Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm

Geng Ku; Min Zhou; Shaoli Song; Qian Huang; John Hazle; Chun Li

doi:10.1021/nn302782y

Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm

Geng Ku, Min Zhou, Shaoli Song, Qian Huang, John Hazle, Chun Li

Research output: Contribution to journal › Article › peer-review

492 Scopus citations

Abstract

Photoacoustic tomography (PAT) is an emerging molecular imaging modality. Here, we demonstrate use of semiconductor copper sulfide nanoparticles (CuS NPs) for PAT with an Nd:YAG laser at a wavelength of 1064 nm. CuS NPs allowed visualization of mouse brain after intracranial injection, rat lymph nodes 12 mm below the skin after interstitial injection, and CuS NP-containing agarose gel embedded in chicken breast muscle at a depth of ∼5 cm. This imaging approach has great potential for molecular imaging of breast cancer.

Original language	English (US)
Pages (from-to)	7489-7496
Number of pages	8
Journal	ACS Nano
Volume	6
Issue number	8
DOIs	https://doi.org/10.1021/nn302782y
State	Published - Aug 28 2012

Keywords

1064 nm laser
CuS nanoparticles
optical imaging
photoacoustic tomography

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

MD Anderson CCSG core facilities

High Resolution Electron Microscopy Facility
Research Animal Support Facility
Small Animal Imaging Facility

Access to Document

10.1021/nn302782y

Cite this

@article{36b78b4dbef84cb9bdfb2a155427094c,

title = "Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm",

abstract = "Photoacoustic tomography (PAT) is an emerging molecular imaging modality. Here, we demonstrate use of semiconductor copper sulfide nanoparticles (CuS NPs) for PAT with an Nd:YAG laser at a wavelength of 1064 nm. CuS NPs allowed visualization of mouse brain after intracranial injection, rat lymph nodes 12 mm below the skin after interstitial injection, and CuS NP-containing agarose gel embedded in chicken breast muscle at a depth of ∼5 cm. This imaging approach has great potential for molecular imaging of breast cancer.",

keywords = "1064 nm laser, CuS nanoparticles, optical imaging, photoacoustic tomography",

author = "Geng Ku and Min Zhou and Shaoli Song and Qian Huang and John Hazle and Chun Li",

year = "2012",

month = aug,

day = "28",

doi = "10.1021/nn302782y",

language = "English (US)",

volume = "6",

pages = "7489--7496",

journal = "ACS Nano",

issn = "1936-0851",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm

AU - Ku, Geng

AU - Zhou, Min

AU - Song, Shaoli

AU - Huang, Qian

AU - Hazle, John

AU - Li, Chun

PY - 2012/8/28

Y1 - 2012/8/28

N2 - Photoacoustic tomography (PAT) is an emerging molecular imaging modality. Here, we demonstrate use of semiconductor copper sulfide nanoparticles (CuS NPs) for PAT with an Nd:YAG laser at a wavelength of 1064 nm. CuS NPs allowed visualization of mouse brain after intracranial injection, rat lymph nodes 12 mm below the skin after interstitial injection, and CuS NP-containing agarose gel embedded in chicken breast muscle at a depth of ∼5 cm. This imaging approach has great potential for molecular imaging of breast cancer.

AB - Photoacoustic tomography (PAT) is an emerging molecular imaging modality. Here, we demonstrate use of semiconductor copper sulfide nanoparticles (CuS NPs) for PAT with an Nd:YAG laser at a wavelength of 1064 nm. CuS NPs allowed visualization of mouse brain after intracranial injection, rat lymph nodes 12 mm below the skin after interstitial injection, and CuS NP-containing agarose gel embedded in chicken breast muscle at a depth of ∼5 cm. This imaging approach has great potential for molecular imaging of breast cancer.

KW - 1064 nm laser

KW - CuS nanoparticles

KW - optical imaging

KW - photoacoustic tomography

UR - http://www.scopus.com/inward/record.url?scp=84865586016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865586016&partnerID=8YFLogxK

U2 - 10.1021/nn302782y

DO - 10.1021/nn302782y

M3 - Article

C2 - 22812694

AN - SCOPUS:84865586016

SN - 1936-0851

VL - 6

SP - 7489

EP - 7496

JO - ACS Nano

JF - ACS Nano

IS - 8

ER -

Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

Other files and links

Fingerprint

Cite this