Correction: First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors (Journal of Experimental & Clinical Cancer Research, (2023), 42, 1, (76), 10.1186/s13046-023-02649-6)

Christopher B. Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D. Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lipkowitz, Alexandra Zimmer, Jung min Lee, Miroslava Pavelova, Erin N. Villanueva, Kathryn Trewhitt, B. Brooke Solarz, Maria Fergusson, Sharon A. Mavroukakis, Anjum ZakiKwong Y. Tsang, Philip M. Arlen, Christina M. Annunziata

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

Following publication of the original article [1], an error was identified in Fig. 2, specifically: Fig. 2b - CL/F (mL/hr) needs to be corrected in CL/F (L/hr) Furthermore, two Supplementary Materials should also be uploaded. The added Supplementary Materials are: Additional file 7: Supplementary Materials and Methods. Additional file 8: NEO-201 protocol. This modification does not affect the integrity of the results. Clinical Pharmacokinetics of NEO-201 A. NEO-201 serum concentrations averaged for each dose level and plotted over time. B. Noncompartmental analysis of first dose of NEO-201 including the mean estimates for relevant PK parameters during dense PK sampling following the first dose given on C1D1. *Data presented as arithmetic means (%CV) due to low numbers in each group. 1 Two patients had inaccurate estimates of C1D1 clearance and volume due to an overestimation of AUCinf. 2 One patient had insufficient terminal data to accurately estimate a half-life, thus clearance and volume too. 3 Four patients had inaccurate estimates of C1D1 clearance and volume due to an overestimation of AUCinf. 4 One patient had insufficient terminal data to accurately estimate a half-life, thus clearance and volume too. 5 Two patients had inaccurate estimates of C1D1 clearance and volume due to an overestimation of AUCinf. C. Individual NEO-201 serum concentration–time profiles of 1.0 mg/kg cohort. D-E. Individual NEO-201 serum concentration–time profiles of patients in 1.5 mg/kg cohort (D) and 2.0 mg/kg cohort (E). F-G. Differences in NEO-201 distribution volume by sex (F) and body size (G).

Original languageEnglish (US)
Article number102
JournalJournal of Experimental and Clinical Cancer Research
Volume42
Issue number1
DOIs
StatePublished - Dec 2023
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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