TY - JOUR
T1 - Correlation of cervical cancer mortality with reproductive and dietary factors, and serum markers in china
AU - Guo, Wan De
AU - Hsing, Ann W.
AU - Li, Jun Yao
AU - Chow, Wong Ho
AU - Blot, William J.
AU - Chen, Jun Shi
N1 - Funding Information:
• Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. ** Epidemiology and Biostatislics Program, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. * Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, People's Republic of China. Reprint requests to: Dr Ann W Hsing, National Cancer Institute, 6130 Executive Blvd EPN 415, Bethesda, MD 20892-7368, USA.
PY - 1994/12
Y1 - 1994/12
N2 - Guo W-D (Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China), Hsing A W, Li J-Y, Chen J-S, Chow W-H and Blot W J. Correlation of cervical cancer mortality with reproductive and dietary factors, and serum markers in China. International Journal of Epidemiology 1994; 23: 1127-1132. Background. Cervical cancer is the second leading cause of cancer death among Chinese women. Within China, a considerable geographical variation in mortality rates has been observed, but the reasons are not well understood. Methods. Cervical cancer rates were examined in relation to indices of reproductive factors, dietary habits, and selected serum biomedical markers in 65 rural Chinese counties. Results. Cervical cancer mortality rates correlated positively and significantly with antibodies to herpes simplex virus type 2 (HSV-2) (r = 0.40, P < 0.01), serum levels of ferritin (r = 0.33, P < 0.01), body mass index (BMI) (r = 0.42, P < 0.01) and cigarette smoking (r = 0.51, P < 0.05) and negatively and significantly with age at first birth (r = -0.51, P < 0.01), consumption of green vegetables (r = -0.40, P < 0.01) and animal foods (r = -0.40, P < 0.01), and serum levels of selenium (r = -0.26, P < 0.05). When these variables were considered in the multiple regression analysis, early age at first birth and higher BMI were positively associated with cervical cancer mortality, while consumption of green vegetables and animal foods were negatively correlated. In the serum model, infection with HSV-2 and low levels of sex hormone binding globulin (SHBG) were positively related to cervical cancer mortality. No relation was found for consumption of fruits. Conclusions. Although limitations of these ecologic data preclude causal inferences, findings in this study, including associations with HSV-2 infection, early age at first birth, consumption of green vegetables and animal foods, may provide dues to cervical cancer aetiology.
AB - Guo W-D (Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China), Hsing A W, Li J-Y, Chen J-S, Chow W-H and Blot W J. Correlation of cervical cancer mortality with reproductive and dietary factors, and serum markers in China. International Journal of Epidemiology 1994; 23: 1127-1132. Background. Cervical cancer is the second leading cause of cancer death among Chinese women. Within China, a considerable geographical variation in mortality rates has been observed, but the reasons are not well understood. Methods. Cervical cancer rates were examined in relation to indices of reproductive factors, dietary habits, and selected serum biomedical markers in 65 rural Chinese counties. Results. Cervical cancer mortality rates correlated positively and significantly with antibodies to herpes simplex virus type 2 (HSV-2) (r = 0.40, P < 0.01), serum levels of ferritin (r = 0.33, P < 0.01), body mass index (BMI) (r = 0.42, P < 0.01) and cigarette smoking (r = 0.51, P < 0.05) and negatively and significantly with age at first birth (r = -0.51, P < 0.01), consumption of green vegetables (r = -0.40, P < 0.01) and animal foods (r = -0.40, P < 0.01), and serum levels of selenium (r = -0.26, P < 0.05). When these variables were considered in the multiple regression analysis, early age at first birth and higher BMI were positively associated with cervical cancer mortality, while consumption of green vegetables and animal foods were negatively correlated. In the serum model, infection with HSV-2 and low levels of sex hormone binding globulin (SHBG) were positively related to cervical cancer mortality. No relation was found for consumption of fruits. Conclusions. Although limitations of these ecologic data preclude causal inferences, findings in this study, including associations with HSV-2 infection, early age at first birth, consumption of green vegetables and animal foods, may provide dues to cervical cancer aetiology.
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U2 - 10.1093/ije/23.6.1127
DO - 10.1093/ije/23.6.1127
M3 - Article
C2 - 7721512
AN - SCOPUS:0028578151
SN - 0300-5771
VL - 23
SP - 1127
EP - 1132
JO - International journal of epidemiology
JF - International journal of epidemiology
IS - 6
ER -