TY - JOUR
T1 - Correlative studies in clinical trials
T2 - A position statement from the international thyroid oncology group
AU - Bible, Keith C.
AU - Cote, Gilbert J.
AU - Demeure, Michael J.
AU - Elisei, Rossella
AU - Jhiang, Sissy
AU - Ringel, Matthew D.
N1 - Publisher Copyright:
Copyright © 2015 by the Endocrine Society.
PY - 2015/12
Y1 - 2015/12
N2 - Objective: Patients with progressive thyroid cancer in distant metastatic sites represent a population with a need fornewtherapeutic options. Aspiring to improve the treatment of such patients, the objective of this position statement from the International Thyroid Oncology Group (ITOG) is to clarify the importance of incorporating high-quality correlative studies into clinical trials. Participants: ITOG was formed to develop and support high-quality multicenter and multidisciplinary clinical trials for patients with aggressive forms of thyroid cancer. The Correlative Sciences Committee of the ITOG focuses on the quality and types of correlative studies included in ITOGassociated clinical trials. Evidence: This document represents expert consensus from ITOG regarding this issue based on extensive collective experience in clinical and translational trials informed by basic science. Consensus Process: The Correlative Studies Committee identified an international writing group representative of diverse specialties, including basic sciences. Drafts were reviewed by all members of the writing group, the larger committee, and the ITOG board. After consideration of all comments by the writing group and modification of the document, the final document was then approved by the authors and the ITOG board. Conclusions: High-quality correlative studies, which include variety in the types of correlates, should be intrinsic to the design of thyroid cancer clinical trials to offer the best opportunity for each study to advance treatment for patients with advanced and progressive thyroid cancer.
AB - Objective: Patients with progressive thyroid cancer in distant metastatic sites represent a population with a need fornewtherapeutic options. Aspiring to improve the treatment of such patients, the objective of this position statement from the International Thyroid Oncology Group (ITOG) is to clarify the importance of incorporating high-quality correlative studies into clinical trials. Participants: ITOG was formed to develop and support high-quality multicenter and multidisciplinary clinical trials for patients with aggressive forms of thyroid cancer. The Correlative Sciences Committee of the ITOG focuses on the quality and types of correlative studies included in ITOGassociated clinical trials. Evidence: This document represents expert consensus from ITOG regarding this issue based on extensive collective experience in clinical and translational trials informed by basic science. Consensus Process: The Correlative Studies Committee identified an international writing group representative of diverse specialties, including basic sciences. Drafts were reviewed by all members of the writing group, the larger committee, and the ITOG board. After consideration of all comments by the writing group and modification of the document, the final document was then approved by the authors and the ITOG board. Conclusions: High-quality correlative studies, which include variety in the types of correlates, should be intrinsic to the design of thyroid cancer clinical trials to offer the best opportunity for each study to advance treatment for patients with advanced and progressive thyroid cancer.
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U2 - 10.1210/jc.2015-2818
DO - 10.1210/jc.2015-2818
M3 - Article
C2 - 26418285
AN - SCOPUS:84950997001
SN - 0021-972X
VL - 100
SP - 4387
EP - 4395
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 12
ER -