TY - JOUR
T1 - Corticosteroids for the treatment of non-arteritic anterior ischemic optic neuropathy
AU - Al-Zubidi, Nagham
AU - McGlynn, Margaret M.
AU - Yalamanchili, Sushma
AU - Lee, Andrew G.
N1 - Funding Information:
The authors were supported by in part by an unrestricted grant from Research to Prevent Blindness. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
PY - 2013/11/27
Y1 - 2013/11/27
N2 - Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of an acute unilateral optic neuropathy in patients older than 50 years of age. Its consequences range from temporarily disabling to permanently blinding. Unfortunately, the pathophysiology of NAION is incompletely understood and no proven effective treatment for NAION currently exists. Numerous theories have been proposed regarding the pathophysiology of NAION including hypoperfusion of the optic nerve, nocturnal hypotension, and in rare cases thrombotic or embolic etiologies. Notably, newer evidence has implicated possible inflammatory processes in NAION leading to potential, theoretical benefit from corticosteroid treatment. This review will spotlight the pros and cons of corticosteroid treatment in NAION.
AB - Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of an acute unilateral optic neuropathy in patients older than 50 years of age. Its consequences range from temporarily disabling to permanently blinding. Unfortunately, the pathophysiology of NAION is incompletely understood and no proven effective treatment for NAION currently exists. Numerous theories have been proposed regarding the pathophysiology of NAION including hypoperfusion of the optic nerve, nocturnal hypotension, and in rare cases thrombotic or embolic etiologies. Notably, newer evidence has implicated possible inflammatory processes in NAION leading to potential, theoretical benefit from corticosteroid treatment. This review will spotlight the pros and cons of corticosteroid treatment in NAION.
KW - Corticosteroids
KW - Non-arteritic anterior ischemic optic neuropathy
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U2 - 10.1586/17469899.2013.852956
DO - 10.1586/17469899.2013.852956
M3 - Review article
AN - SCOPUS:84888102665
SN - 1746-9899
VL - 8
SP - 577
EP - 580
JO - Expert Review of Ophthalmology
JF - Expert Review of Ophthalmology
IS - 6
ER -