TY - JOUR
T1 - Cost-effectiveness analysis of diagnosis and management of cervical squamous intraepithelial lesions
AU - Cantor, Scott B.
AU - Mitchell, Michele Follen
AU - Tortolero-Luna, Guillermo
AU - Bratka, Charlotte S.
AU - Bodurka, Diane C.
AU - Richards-Kortum, Rebecca
N1 - Funding Information:
This study was supported partially by the National Science Foundation/The Whitaker Foundation, The University of Texas M. D. Anderson Cancer Center support grant CA16672, the University Cancer Foundation, and the Business and Professional Women’s Fund.
PY - 1998/2
Y1 - 1998/2
N2 - Objective: To compare five strategies for the diagnosis and treatment of cervical squamous intraepithelial lesions (SILs), including those that incorporate colposcopy and a new technology, fluorescence spectroscopy. Methods: On the basis of a health care perspective, we performed a cost- effectiveness analysis using a decision-analytic model for the diagnosis and management of SILs. We compared the five strategies based on the expected costs and number of cases that were treated appropriately, missed, treated inappropriately, and appropriately not treated in a hypothetical cohort of 100 patients referred after an abnormal Papanicolaou smear. Data on prevalence and operating characteristics were derived from the medical literature. Costs were adjusted from hospital charge data. Results: A see- and-treat strategy based on fluorescence spectroscopy was the least expensive but least effective strategy, costing $160,479 to detect 31.55 cases of cervical precancer accurately in 100 patients. The most expensive strategy was colposcopically directed biopsy, at $311,808 to find 45.78 cases; however, when both tests were used in a see-and-treat modality, slightly more cases were found (46.05) at a lower cost ($285,133). Other strategies were dominated in the base case. The incremental cost-effectiveness of the joint strategy compared with the spectroscopy-only strategy was $8596 per case of cervical precancer detected. Sensitivity analysis showed that the analysis was sensitive to the cost of the new technology of fluorescence spectroscopy. Conclusion: Fluorescence spectroscopy should be considered an important innovation in the diagnosis of SILs as demonstrated by its efficacy and economic advantages.
AB - Objective: To compare five strategies for the diagnosis and treatment of cervical squamous intraepithelial lesions (SILs), including those that incorporate colposcopy and a new technology, fluorescence spectroscopy. Methods: On the basis of a health care perspective, we performed a cost- effectiveness analysis using a decision-analytic model for the diagnosis and management of SILs. We compared the five strategies based on the expected costs and number of cases that were treated appropriately, missed, treated inappropriately, and appropriately not treated in a hypothetical cohort of 100 patients referred after an abnormal Papanicolaou smear. Data on prevalence and operating characteristics were derived from the medical literature. Costs were adjusted from hospital charge data. Results: A see- and-treat strategy based on fluorescence spectroscopy was the least expensive but least effective strategy, costing $160,479 to detect 31.55 cases of cervical precancer accurately in 100 patients. The most expensive strategy was colposcopically directed biopsy, at $311,808 to find 45.78 cases; however, when both tests were used in a see-and-treat modality, slightly more cases were found (46.05) at a lower cost ($285,133). Other strategies were dominated in the base case. The incremental cost-effectiveness of the joint strategy compared with the spectroscopy-only strategy was $8596 per case of cervical precancer detected. Sensitivity analysis showed that the analysis was sensitive to the cost of the new technology of fluorescence spectroscopy. Conclusion: Fluorescence spectroscopy should be considered an important innovation in the diagnosis of SILs as demonstrated by its efficacy and economic advantages.
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U2 - 10.1016/S0029-7844(97)00623-6
DO - 10.1016/S0029-7844(97)00623-6
M3 - Article
C2 - 9469288
AN - SCOPUS:0032006698
SN - 0029-7844
VL - 91
SP - 270
EP - 277
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 2
ER -