Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition

Jennifer L. McQuade; Yn Vashisht Gopal

doi:10.4161/23723556.2014.991610

Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition

Jennifer L. McQuade, Yn Vashisht Gopal

Melanoma Medical Oncology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting OxPhos via a novel mechanism. Here, we discuss the implications of these findings.

Original language	English (US)
Article number	e991610
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.991610
State	Published - Jul 3 2015

Keywords

BRAF
MEK
MITF
NRAS
PGC1α
metabolism

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723556.2014.991610

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title = "Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition",

abstract = "Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting OxPhos via a novel mechanism. Here, we discuss the implications of these findings.",

keywords = "BRAF, MEK, MITF, NRAS, PGC1α, metabolism",

author = "McQuade, {Jennifer L.} and {Vashisht Gopal}, Yn",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Jennifer L McQuade and YN Vashisht Gopal.",

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AU - Vashisht Gopal, Yn

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N2 - Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting OxPhos via a novel mechanism. Here, we discuss the implications of these findings.

AB - Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting OxPhos via a novel mechanism. Here, we discuss the implications of these findings.

KW - BRAF

KW - MEK

KW - MITF

KW - NRAS

KW - PGC1α

KW - metabolism

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Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition

Abstract

Keywords

ASJC Scopus subject areas

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