Critical functions of extracellular matrix in brain metastasis seeding

Arseniy E. Yuzhalin; Dihua Yu

doi:10.1007/s00018-023-04944-z

Critical functions of extracellular matrix in brain metastasis seeding

Arseniy E. Yuzhalin, Dihua Yu

Molecular & Cellular Oncology

Research output: Contribution to journal › Review article › peer-review

Abstract

Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood–brain barrier in brain metastasis; (2) role of ECM in modulating brain metastasis dormancy; (3) regulation of brain metastasis seeding by ECM-activated integrin signaling; (4) functions of brain-specific ECM protein reelin in brain metastasis. Lastly, we consider the possibility of targeting ECM for brain metastasis management.

Original language	English (US)
Article number	297
Journal	Cellular and Molecular Life Sciences
Volume	80
Issue number	10
DOIs	https://doi.org/10.1007/s00018-023-04944-z
State	Published - Oct 2023

Keywords

Blood
Brain barrier
Brain metastasis
Extracellular matrix
Integrin
Reelin

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s00018-023-04944-z

Cite this

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title = "Critical functions of extracellular matrix in brain metastasis seeding",

abstract = "Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood–brain barrier in brain metastasis; (2) role of ECM in modulating brain metastasis dormancy; (3) regulation of brain metastasis seeding by ECM-activated integrin signaling; (4) functions of brain-specific ECM protein reelin in brain metastasis. Lastly, we consider the possibility of targeting ECM for brain metastasis management.",

keywords = "Blood, Brain barrier, Brain metastasis, Extracellular matrix, Integrin, Reelin",

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T1 - Critical functions of extracellular matrix in brain metastasis seeding

AU - Yuzhalin, Arseniy E.

AU - Yu, Dihua

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N2 - Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood–brain barrier in brain metastasis; (2) role of ECM in modulating brain metastasis dormancy; (3) regulation of brain metastasis seeding by ECM-activated integrin signaling; (4) functions of brain-specific ECM protein reelin in brain metastasis. Lastly, we consider the possibility of targeting ECM for brain metastasis management.

AB - Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood–brain barrier in brain metastasis; (2) role of ECM in modulating brain metastasis dormancy; (3) regulation of brain metastasis seeding by ECM-activated integrin signaling; (4) functions of brain-specific ECM protein reelin in brain metastasis. Lastly, we consider the possibility of targeting ECM for brain metastasis management.

KW - Blood

KW - Brain barrier

KW - Brain metastasis

KW - Extracellular matrix

KW - Integrin

KW - Reelin

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Critical functions of extracellular matrix in brain metastasis seeding

Abstract

Keywords

ASJC Scopus subject areas

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