Abstract
There exists a critical period for the development of cervicovaginal lesions in both mice and humans exposed neonatally and antenatally to sex hormones. Mammary glands from year-old female BALB/c mice exposed neonatally to 20 μg estradiol for 5 days commencing at 1 day of age showed the most mammary abnormalities, significantly greater than in controls (P < 0.005). The incidence of abnormalities declined when treatment was begun after Day 1. Treatments begun after Day 3 did not result in this structural pattern. Mice ovariectomized after treatment all had inactive mammary glands with no abnormalities. There is a critical exposure period for the later occurrence of mammary gland abnormalities. However, the aberrant secretory state which accompanies these mammary gland alterations may be a consequence of permanent alteration in ovarian function or its endocrine control.
Original language | English (US) |
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Pages (from-to) | 239-242 |
Number of pages | 4 |
Journal | Proceedings of the Society for Experimental Biology and Medicine |
Volume | 172 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1983 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology