Cross-regulation of histone modifications

John A. Latham; Sharon Y.R. Dent

doi:10.1038/nsmb1307

Cross-regulation of histone modifications

John A. Latham, Sharon Y.R. Dent

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Review article › peer-review

338 Scopus citations

Abstract

Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show substantial cross-regulation, providing a wealth of regulatory potential. New insights into the communication between modifications on histones have emerged in recent years. This review assesses the current understanding of cross-regulation of histone modifications and identifies future questions to be addressed in this field.

Original language	English (US)
Pages (from-to)	1017-1024
Number of pages	8
Journal	Nature Structural and Molecular Biology
Volume	14
Issue number	11
DOIs	https://doi.org/10.1038/nsmb1307
State	Published - Nov 2007

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1038/nsmb1307

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title = "Cross-regulation of histone modifications",

abstract = "Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show substantial cross-regulation, providing a wealth of regulatory potential. New insights into the communication between modifications on histones have emerged in recent years. This review assesses the current understanding of cross-regulation of histone modifications and identifies future questions to be addressed in this field.",

author = "Latham, {John A.} and Dent, {Sharon Y.R.}",

note = "Funding Information: We thank A. Loyola and R. Chosed for critical comments and suggestions. J.A.L. is supported in part by a fellowship by the American Legion Auxiliary. Aspects of this work were supported by US National Institutes of Health grant GM067718 and a grant from the Robert A. Welch Foundation (G1371) to S.Y.R.D. We apologize to colleagues whose work was not cited owing to space limitations.",

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N1 - Funding Information: We thank A. Loyola and R. Chosed for critical comments and suggestions. J.A.L. is supported in part by a fellowship by the American Legion Auxiliary. Aspects of this work were supported by US National Institutes of Health grant GM067718 and a grant from the Robert A. Welch Foundation (G1371) to S.Y.R.D. We apologize to colleagues whose work was not cited owing to space limitations.

PY - 2007/11

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N2 - Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show substantial cross-regulation, providing a wealth of regulatory potential. New insights into the communication between modifications on histones have emerged in recent years. This review assesses the current understanding of cross-regulation of histone modifications and identifies future questions to be addressed in this field.

AB - Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show substantial cross-regulation, providing a wealth of regulatory potential. New insights into the communication between modifications on histones have emerged in recent years. This review assesses the current understanding of cross-regulation of histone modifications and identifies future questions to be addressed in this field.

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Cross-regulation of histone modifications

Abstract

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