TY - JOUR
T1 - Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis
AU - Huang, Chen
AU - Xie, Keping
N1 - Funding Information:
We thank Don Norwood for editorial comments. This work is supported in part by grants R01-CA129956 , R01-CA148954 , and R01CA152309 (to K. Xie) from the National Cancer Institute , National Institutes of Health and grant 81101844 (to C. Huang) from the National Natural Science Foundation of China .
PY - 2012/2
Y1 - 2012/2
N2 - Pancreatic cancer progression is attributed to genetic and epigenetic alterations and a chaotic tumor microenvironment. Those diverse " upstream signal" factors appear to converge on specific sets of central nuclear regulators, namely, transcription factors. Specificity Protein 1 (Sp1) and signal transducer and activator of transcription 3 (Stat3) are central transcription factors that regulate a number of pathways important to tumorigenesis, including tumor cell-cycle progression, apoptosis, angiogenesis, metastasis, and evasion of the immune system. Recently, researchers demonstrated many types of crosstalk of Sp1 and Stat3 in tumor signal transduction and that these factors function cooperatively to activate targeted genes and promote tumorigenesis in pancreatic cancer. Therefore, targeting both Sp1 and Stat3 is a potential preventive and therapeutic strategy for pancreatic cancer.
AB - Pancreatic cancer progression is attributed to genetic and epigenetic alterations and a chaotic tumor microenvironment. Those diverse " upstream signal" factors appear to converge on specific sets of central nuclear regulators, namely, transcription factors. Specificity Protein 1 (Sp1) and signal transducer and activator of transcription 3 (Stat3) are central transcription factors that regulate a number of pathways important to tumorigenesis, including tumor cell-cycle progression, apoptosis, angiogenesis, metastasis, and evasion of the immune system. Recently, researchers demonstrated many types of crosstalk of Sp1 and Stat3 in tumor signal transduction and that these factors function cooperatively to activate targeted genes and promote tumorigenesis in pancreatic cancer. Therefore, targeting both Sp1 and Stat3 is a potential preventive and therapeutic strategy for pancreatic cancer.
KW - Angiogenesis
KW - Metastasis
KW - Therapy
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U2 - 10.1016/j.cytogfr.2012.01.003
DO - 10.1016/j.cytogfr.2012.01.003
M3 - Review article
C2 - 22342309
AN - SCOPUS:84862798695
SN - 1359-6101
VL - 23
SP - 25
EP - 35
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 1-2
ER -