Abstract
There are approximately 800 new cases of acute promyelocytic leukemia (APL) in the United States every year. APL is rarely observed in pediatric populations, and accounts for less than 5-10% of all pediatric cases of acute myeloid leukemia (AML). APL typically presents with symptoms related to the pancytopenia such as fatigue due to anemia, bleeding and bruising secondary to thrombocytopenia, and infections attributed to a lack of functioning leukocytes. The presentation of APL in the central nervous system (CNS) is a rare phenomenon. In addition, APL has a dismal prognosis when found in the CNS. In this case study, we describe a unique presentation of pediatric APL with cryptic insertion of the promyelocytic leukemia (PML)-retinoic acid receptor-alpha (RARA) fusion protein with a surprisingly excellent recovery.
Original language | English (US) |
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Pages (from-to) | 270-273 |
Number of pages | 4 |
Journal | Annals of clinical and laboratory science |
Volume | 50 |
Issue number | 2 |
State | Published - Mar 2020 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine